Our laboratory has several interests - nucleic acid structure, interactions, folding, design, covalent damage and deformation. We attempt to understand nucleic acid structure and interactions with other biological molecules. We predict and determine 3-dimensional structures of nucleic acids as modulated and deformed by sequence, covalent damage, proteins, other nucleic acid molecules, intercalators, groove binders, ions, etc. One of our major current efforts is to try to understand relationships between nucleic acid structure and electrostatic forces. We are also interested in three-dimensional structures of a DNA complexes of mono- and bis-intercalators. Williams home =>

				Crystals going to the space station.