STRUCTURE TEACHING TOOL
PROTEINS AND NUCLEIC ACIDS

(revision March 6, 2003)
Initial development support provided by the NSF CAREER Program
Loren Williams (loren.williams@chemistry.gatech.edu)
Description: This learning tool is designed to facilitate the incorporation 3D structures and their visualization into the teaching of biochemistry and biophysics.

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  Topic
Subject

1
Background
Kinetics
Enthalpy, entropy and free energy
Molecular interactions

2
The hydrogen bond
Ions
The hydrophobic effect
Small molecules

3
Protein monomers and oligomers
Amino acids
The peptide bond
Torsion angles Phi and Psi

4
Protein secondary structure
alpha-Helix
beta-Sheet
Loops and turns

5
Protein Folds
Fibrous proteins
alpha-Helical proteins
alpha-Helical/beta-Sheet proteins
Anti-parallel beta-sheet proteins

6
Protein/Metal Interactions
Metals Page

6a
Protein/Nucleotide Interactions
Rossman Fold Page

7

Nucleic acid structure
ribose/deoxyribose
phosphodiester backbone
bases
base pairs, triplets and quartets
A,B,Z conformation
Supercoiling

7a
RNA
motifs
tRNA
Ribosome

8
Interactions of nucleic acids with small molecules
Water
Magnesium
Spermine
Minor groove binders
Intercalators and Bis-intercalators

9
Interactions of nucleic acids with proteins
Helix-turn-helix
Zinc Fingers
ZIP
Helix-loop-helix
Beta-ribbon
Restriction and Modification Enzymes
tRNA synthetases
Rev response element/rev peptide
Polymerases
Nucleosome

10
Catalysis
Enzyme active sites, Serine Proteases, Ribozymes, DNAzymes

11
Enzymes that bind nucleotides
Structure of Viruses
Recognition of Foreign Molecules by the Immune System

 12
phylogony

12
Databases
PDB, NDB, CSD, Genbank, PubMed, Science Citation Index, CATH

13
Display and Manipulation
Rasmol Tutorial (download Rasmol)

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