3D Intensity Map

Extraction of Mass Spectral Data from Total Ion Trace

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3D Intensity Map

Dr. Manshui Zhou

Office:  ES&T L2-114

Office Phone:  404-385-4428

E-mail: mzhou8@mail.gatech.edu

Education

Jan 2007 - Present     Georgia Institute of Technology, Post-Doc

Dec 2006                  University of Illinois, Chicago, Ph.D. Chemistry

Research Interests

LC/MS-based Metabonomics of Human Serum for Early Ovarian Cancer Diagnostics

Due to the asymptomatic nature of the ovarian cancer disease and lack of predictive biomarkers, only 19% of women are diagnosed in the early stages, while the average survival rate is only 29% if diagnosed in the advanced stages. Therefore, screening for specific predictive biomarkers for the early-stage ovarian cancer is a major public health priority.

Currently I am pursuing a project directed towards the high-throughput discovery of ovarian cancer biomarkers via state-of-the art metabonomic and chemometric methodologies in two areas:

1. Serum based comparative metabonomics study using reversed phase high performance liquid chromatography-time of flight mass spectrometry (RP-HPLC-TOF MS) combined with multivariate statistical analysis.

2. Cyst fluid based comparative metabonomics study using direct analysis in real time TOF MS (DART-TOF MS) combined with multivariate statistical analysis.

Publications

1. "Serum biomarker profiling by solid-phase extraction with particle-embedded micro tips and matrix-assisted laser desorption/ionization mass spectrometry", Arti Navare, Manshui Zhou, John McDonald, Fernando G. Noriega, M.Cameron Sullards, and Facundo M. Fernanadez, Rapid Commun. Mass Spectrom.,2008, 22 (7), 997-1008.