****************************************************************************** From: mrdio007@aol.com (MrDio007) Date: 1 Jan 1997 02:57:28 GMT Subject: Re: rat poison Organization: AOL http://www.aol.com The inverted chromatograms are often seen when the instrument is scanned from a relatively low starting value. Although it depends upon the solvent system/ionization mode the following are a few ideas. In ESI/APCI if you scan low there will be the inevitible chemical background detectable under ALL conditions. This background is both chemical species in the form of "contaminants" and cluster ions forming and reforming in the source. The great softness of atmospheric sources that every one loves also allows the operation of these under conditions in which cluster formation is more or less favored. A headache for some and plain old chemistry to others. Basically the input of the desolvation energy that removes the LC solvent from the analyte can also fragment the analyte if applied in too large an amount. Conversely you get clusters of LC solvent and analyte if you run it it too low. You also get clusters of LC solvent without analyte. Like three methanols, a wate,r and a proton. These are frequently observed as a series of ions with a statisticall bell curve like distribution with a typical spacing value of say water or methanol. Now under some conditions delicate labile analytes may require lower energy inputs to avoid fragmentation. These same conditions may favor cluster formation at low mass. So what to do? ANS: Scan from a mass Higher than the inevitable background ions. Usually these sources are being used because the analysis won't work by EI/CI with a GC (smaller molecules are usually more volatile and /or less labile). The inverted chromatograms can occur when the desired analyte elutes off the column in to the busy source (as explained above) and begins to compete for ionization. If the source contains a plasma like APCI then the plasma cycle components and clusters grabbing up the charges will begin to donate some to (or be robbed by) the analyte. If you are scanning low enough you are actually monitoring the depletion of these species (and so the deplelted chromatogram (observeable in GC/MS using CI as well) If you know the mass of your charged analyte then the plotting out of this value should give you a nice single ion plot that you can use to quantitate your species. Even when the RIC or TIC looks bad. The background ions may cahnage over a gradient as the solvent compostion cahnges. So you might consider that as well before you decide what starting m/z value you are going to use for your analysis. ****************************************************************************** From: mrdio007@aol.com (MrDio007) Date: 1 Jan 1997 03:02:26 GMT Subject: Re: rat poison Organization: AOL http://www.aol.com Sorry I forgot to sign that previous message on Rat poison and inverted chromatograms. The nice thing is that you don't usually fragment the molecules with these sources so ther is really not much reason to look down low. Of course there are exceptions. ps A frequent error is the failure to differentiate polymer background cont. and cluster formation when something is not right with the source (equipment or operator error). Matt Sweeney Mass-Spec Gun for hire ****************************************************************************** From: Christopher Kaine Date: Tue, 31 Dec 1996 23:35:54 -0800 Subject: Thanks Organization: OneNet Communications HUB News Server Hello Finnigan Customers: I am writing to say thanks for allowing me to be part of your world. My tenure as one of Finnigan's Technical Specialists/Institute Instructors has come to an involuntary conclusion. It has been my honor and pleasure to assist some of you in the use and maintenance of your instrumentation for the past eight years. I plan on frequenting this newsgroup to continue volunteering my expertise/experience. Again, I thank you all. Cordially; Christopher J. Kaine ****************************************************************************** From: gbird@superlink.net (George ) Date: Wed, 01 Jan 1997 14:34:57 GMT Subject: Re: Software to interpret GC-MS spectra from first principles Organization: SuperNet Inc. (908) 828-8988 On 31 Dec 1996 09:16:55 -0500, cody@jeol.com (Chip Cody) wrote: }Some research has gone into predicting fragmentation based on a known }structure -- I dabbled with this myself and I saw a really nicely done }version of a program that actually draws reaction mechanisms presented }by someone from NIST at a recent ASMS meeting. However, I understand that }this program is still in the development stages. } Chip; I was unable to attend the ASMS this year, if you hear any other information about this program, could you let me know? thanks.... ****************************************************************************** From: Terry Hulbert Date: Thu, 02 Jan 1997 12:26:15 -0800 Subject: Physics Express Letters Organization: Institute of Physics Publishing Institute of Physics Publishing has launched the latest version (v2.0) of Physics Express Letters (PEL). PEL now offers FREE access to all letters and rapid communications from 12 of our journals. Journals within the service include Journal of Physics B, Journal of Physics: Condensed Matter, Classical & Quantum Gravity, Measurement & Science Technology and Semiconductor Science & Technology. You can find Physics Express Letters at Terry Hulbert Producer, Electronic Products Institute of Physics Publishing ****************************************************************************** From: pvang@sci.kun.nl (Peter van Galen) Date: 6 Jan 1997 09:15:53 +0100 Subject: Re: Software to interpret GC-MS spectra from first principles Organization: University of Nijmegen, The Netherlands In <5agb24$en0@acmey.gatech.edu> gbird@superlink.net (George ) writes: }On 31 Dec 1996 09:16:55 -0500, cody@jeol.com (Chip Cody) wrote: }}Some research has gone into predicting fragmentation based on a known }}structure -- I dabbled with this myself and I saw a really nicely done }}version of a program that actually draws reaction mechanisms presented }}by someone from NIST at a recent ASMS meeting. However, I understand that }}this program is still in the development stages. }} }Chip; } I was unable to attend the ASMS this year, if you hear any other }information about this program, could you let me know? }thanks.... Please attach me as another interested person. thanks in advance |___________________________ Peter M. van Galen, |____ Mass Spectrometry |__________________ Organic Chemistry Department |_ Nijmegen University |___ Toernooiveld 1, 6525 ED Nijmegen,Netherlands ****************************************************************************** From: George Shpenkov Date: Mon, 06 Jan 1997 14:11:14 +0200 Subject: New Theory of Matter-Space-Time (long article) Organization: Technical University in Bydgoszcz For : Scientists and students with an interest in the physics, mathematics, chemistry, philosophy, logic, interdisciplinary sciences. ------------------------------------------------------------------------ ALTERNATIVE PICTURE OF THE WORLD by LEONID G. KREIDIK & GEORGE P. SHPENKOV "...The book is for those who think the physical theories, far from ending, have only just begun..." Published by GEORGE SHPENKOV Bydgoszcz, Poland _____________________________________________________________________ Physics, Chemistry, Mathematics, Philosophy, Logic, Interdisciplinary Sciences ------------------------------------------------------------------------ Alternative Picture of the World By L.G. Kreidik, Polytechnic Academy, Minsk, Belarus G.P. Shpenkov, Technical University, Bydgoszcz, Poland Dialectics of Nature, considered primarily in this book, is an integrated physical-mathematical science which represents, in the broad sence of the word, a logical-philosophical system of knowledge about Nature. The authors have concentrated on general problems of physical axioms, which are considered within the dialectics, including logic, philosophy and mathematics. The wave three-dimensional material-ideal numerical field and dialectical logic of the same structure constitute the basis of the dialectics. The book consists of three volumes: Volume 1. 1. Mathematical expression of the main categories of philosophy and logic. 2. Kinematics and dynamics of exchange. Volume 2. 3. Structure of Space of the Universe 4. Electrostatic and electromagnetic fields. 5. Particles and exchange in an electormagnetic field. Volume 3. 6. Atomic structure of matter-space-time and physical properties of substance. 7. Physics and philosophy. Contents of the second and third volumes is based on the notions described in the first one. VOLUME 1. As is known, the main characteristic feature of dialectics is a juncture of the material and ideal Worlds, which is the most important contradiction of the Universe. This contradiction joins all the other contradictions of the Universe. Of all philosophic systems, dialectics alone expresses the objective contradictions most completely by considering them as a basis for everything that exists in the Universe. Translating the concept of contradictions and noncontradictions into the language of mathematics, the authors have constructed a mathematical description based on the mathematics of the material-ideal numerical field, which allows sufficiently accurate expression of the laws of dialectics in mathematical form and, proceeding from them, a description of axioms of physics, and mathematics. The language of the main notions and axioms of physics and mathematics is extended substantially, the theory of discrete derivatives and the quantitative-qualitative version of operational calculus are presented, and notions of a multiplicative derivative and multiplicative integral are introduced. Against to classical tradition, motion and rest are concerned in close nonseparable contradictory relation. This dialectical bond are expressed by a dialectical material-ideal field of numbers and a binary set of notions. Every binary pair of the notions describes corresponding aspects of motion and rest giving opportunity to see both kinetic and potential sides of kinematics of real processes. Description of dynamics has also dialectical binary character. The nonforce description of relations between objects, called as "exchange", differs in principle from the classical approach based on the notion of force interaction. Exchange, in wide sence of this word, is here the exchange by motion, rest, space, matter, arbitrary state, etc. VOLUME 2. A new approach based on solution of the wave equation in the material-ideal qualitative-quantitative space was used for description of the internal nucleonic structure of atoms. The relation of the internal geometry of nucleonic nodes of atoms with the crystal shape was found. In the present theory, the electrostatic field is an ultra frequency field, which brings about new physical constants. The theory of electric charges is presented and a charge formula is obtained and used to calculate the electronic charge. The theory of mass is expounded and used to obtain formulae for electron and nucleon masses. This will allow new relations between the basic physical constants to be established, in particular, the mass of the electron and its charge. On the basis of the wave theory, new calculation formulae are given for some mass and energy exchange coefficients. In particular, the theory of Planck constant is considered and its formula is presented. All constants and variables are expressed in a system of units that does not contain fractional powers in the formulae of dimensions. VOLUME 3. It is shown that classical physical phenomena of transfer (diffusion, viscosity, thermal conductivity) are naturally described in terms of the suggested nucleonic model of atoms. It represents a system of shells with discrete points-nodes of wave space completed by nucleons, i.e. an atom of the space has not a customary nucleous of a classical atomic model. Moreover, a nucleon of the atom has the megaspace apart from microspace. Gravitational shells of the nucleon correlates with corresponding shells of star systems. Other processes, such as the motion of nucleons and of nucleon excitations (electrons) in solids (electric resistance, Hall ffect), absorption, radiation, scattering energy, etc. confirm the correctness of the presented model of an atomic space as well. The nucleon structure of atoms is considered in their agreement with periodic table as a sequential series of the periodicly recurring and nonrecurring solutions of the wave equation. Nonlinear phenomena are dealt with in the volume. The central place occupies the consideration of Doppler effect, which is closely related to the theory of relativity and Mössbauer effect, etc. New QUGCS system of units forms a significant part of the volume. Some dialectical aspects of the Universe, main postulates of dialectical philosophy and logic, elements of the theory of sets and concrete dialectics are touched upon here briefly. Copyright © 1996 by Leonid G. Kreidik & George P. Shpenkov ISBN 83-906156-0-6 (Vol. 1, 158 pages, soft cover) ISBN 83-906156-1-4 (Vol. 2, 164 pages, soft cover) ISBN 83-906156-2-2 (Vol. 3, 186 pages, soft cover) Publication: November-December 1996 Price: US$ 150 (per three volumes together) ------------------------------------------------------------------------ ORDER FORM Send this Order to: George Shpenkov, Stroma 13A/402, Bydgoszcz, 85-158 Poland Rush Orders: FAX 48-52-438643 Please send me______copy(ies) of_______________________________________ ________________________________________________________________________ All orders must be pre-paid (publisher pays postage) Payment to: PBK SA w Warszawie. O/Gdansk-F/Bydgoszcz, ul. Chodkiewicza 15, Bydgoszcz, 85-197 Poland 370800-62095-2700-2-1-787-1 Name __________________________________________________ Address ________________________________________________________________ ________________________________________________________________________ Signature__________________________ Date_____________________________ Dr. LEONID G. KREIDIK has long been working at the Polytechnic Academy in Minsk as a lecturer. He teaches physics. His scientific interest, past and present, deals mainly with the analysis of the groundwork of physics on the basis of world achievements in Philosophy, Logic, system analysis and modern computer technologies. His fanatic faithfulness to the fundamental science ever since his graduation from the Physics Department in 1955 led him to the mathematically strict solutions of general physics fundamentals not published before and generalized in this book. His ideas has not been coincided to the official philosophy at that time. He has predicted, many years ago, possibilities of the nuclear catastrophes paying attention to the famous scientists at the nuclear technology defects. He has announced about it, before the Chernobyl disaster, in the Center of Nuclear Research in Dubna to Academician George Fliorov and Nobel prize winner Igor Tamm in 1970. Dr. GEORGE P. SHPENKOV is currently a Professor of the Institute of Mathematics and Physics at the Technical University in Bydgoszcz, Poland. He graduated from the Radiophysics Department in Minsk, 1965, and then worked at the Physical-Technical Institute name after Ioffe (St. Petersburg). He defended his Ph.D. there in the Physics of Semiconductors. He discovered laser radiation in A2B4C52 semiconductor compounds and generation of the second harmonic in them. He has D.Sc. degree in Solid State Physics; he also worked at the Radiation Introscopy Laboratory and at the Substance Structure Department of the University in Minsk. University lecture classes he has taught include all sections of General Physics, Quantum Mechanics and Quantum Chemistry, Contemporary Physics (for philosophers), etc. He is well known in science (tribology) as the author of three books, the latest of which is "FRICTION SURFACE PHENOMENA" (ELSEVIER, Amsterdam, 1995, 358 pages). He is one of the discoverers of the "HYDROGEN WEAR OF METALS" phenomenon. He is also the author of 16 inventions and approximately 90 publications. His professional education and experience in science and teaching Physics is wide enough to allow him to deeply understand the problems of general physical rules, to have doubts about the central concepts of Modern Physics and to attempt to dare their complete analysis. Subjects of current interest include an analysis of basic concepts of Physics and their co-ordination with Logic and Philosophy. ISBN 83-906156-0-6 (Vol. 1) ISBN 83-906156-1-4 (Vol. 2) ISBN 83-906156-2-2 (Vol. 3) ****************************************************************************** From: cogsol@barnes.globalnet.co.uk (Cognitive Solutions Limited) Date: Mon, 06 Jan 1997 16:31:16 GMT Subject: Free Training Software Demos Organization: * Try our website for free demos of training Software for Analytical Techniques. http://www.globalnet.co.uk/~cogsol ****************************************************************************** From: STROHJ@pfizer.com Date: Mon, 6 Jan 1997 14:28:38 -0500 Subject: Free mass spectrometer Organization: * From: Justin G. Stroh, Pfizer Inc. We are looking to find a good home for a BioIon mass spectrometer, which is in good working order. The instrument is free for the asking with two caveats. First, the person(s) receiving the instrument must pick it up at Pfizer's research facility in Groton, CT. The second is that the person(s) picking up the instrument must have a valid NRC license to use californium-252. If you know of such a person, please have them contact me directly at strohj@pfizer.com. Thank you for your help in this matter. Justin G. Stroh strohj@pfizer.com ****************************************************************************** From: tectra@t-online.de (Andreas Gati) Date: 7 Jan 1997 21:11:02 GMT Subject: ion source / duoplasmatron needed Organization: tectra GmbH Physikalische Instrumente Hi all, can anyone help me finding an ion source / duoplamatron source with the following specs: - mass seperation: H, AR (or Ne) - energy range 500 eV to 10 keV (at least 5) currents at 500 eV: H > 10 uA, Ar > 100 uA - spot size 2 mm dia Any help appreciated with thanks Andreas Gati ****************************************************************************** From: eri@mindlink.bc.ca (Elemental Research Inc.) Date: Tue, 7 Jan 1997 21:57:00 GMT Subject: Parts for VG PQ-I ICPMS for sale Organization: MIND LINK! - British Columbia, Canada As I stated here a couple of weeks ago, we have some spare parts for an old VG Plasmaquad-I ICP-MS for sale. We have sold the bulk of them (as the result of posting to this newsgroup) but some still remain. Last chance to pick up these hard to find items. Price List (all prices in $US) A. Working Units ------------- Lens supply (s/n 1894-05) $1480.00 Lens supply (s/n 1993-03) $1480.00 Power control (s/n 3001) $ 740.00 RF coupler $ 370.00 B. Main power board PCB's: ----------------------- MR504-200C3 issue 2 (1) $ 148.00 each MR504-204C3 issue 3 (1) $ 148.00 each MR504-207C3 issue 1 (2) $ 148.00 each MR504-202C2 issue 5 (2) $ 148.00 each MR504-205C3 issue 3 (2) $ 148.00 each MR504-201C3 issue 2 (4) $ 148.00 each MR504-203C3 issue 2 (2) $ 148.00 each MR504-2013C3 issue 1 (2) $ 148.00 each C. Quad Controller Boards ------------------------- MA 3020-200 P/D (1) $ 148.00 MA 495-69C (1) $ 148.00 MA 495-70C (1) $ 148.00 MA 495-63C (1) $ 148.00 MA 495-65C (1) $ 148.00 MA 495-76C (1) $ 148.00 MA 485-62C (1) $ 148.00 D. Misc. --------------- Edwards vacuum controller model H1105 (1) $2000.00 Quad RF generator, valve type (2) $2000.00 Best regards, Ray Ford Elemental Research North Vancouver, B.C. Tel: (604) 986-0445 Fax: (604) 986-0071 Email: eri@mindlink.bc.ca ****************************************************************************** From: Ed Nieves Date: Thu, 9 Jan 1997 12:32:15 -0500 Subject: Position open: Research Associate Organization: * Position open: Research Associate Salary $25-40,000 per year, depending on experience. The project involves isolating novel peptides that may be involved with a variety of biological processes, including obesity, aggression, anxiety, and many others. The peptides are isolated from mouse tissues by purification on affinity columns and HPLC, or by 2D gels. Sequence analysis is then performed by tandem MS and/or Edman degradation. Experience with peptide isolation and/or mass spectrometry is desirable. For further details, contact Lloyd Fricker (fricker@aecom.yu.edu) Dept. of Molecular Pharmacology Albert Einstein College of Medicine. ****************************************************************************** From: kosse@pioneer.state.nd.us (Kevin J. Kosse) Date: Fri, 10 Jan 1997 16:16:35 GMT Subject: Borneol and related compounds Organization: U S WEST - !NTERACT Services Does anyone have a method, or a reference to a method, for borneol, iso-borneol, or methyl-iso-borneol in water at part-per-trillion levels? TIA Kevin J. Kosse ****************************************************************************** From: "G. Wolmershaeuser" Subject: MS Simulation Program Date: Fri, 10 Jan 1997 11:18:36 +0100 Organization: University of Kaiserslautern [This is forwarded from sci.chemistry.analytical. Dr. Wolmershaeuser has found two programs that simulate mass spectra, but needs something more talented and powerful. DB] I am looking for a good and versatile simulation program for mass spectra. PD or shareware for UNIX or WINDOWS(NT or 95) platorm preferred! Any idea? Thanks a lot in advance -- G. Wolmershaeuser FB Chemie, Univ. Kaiserslautern wolmersh@chemie.uni-kl.de ****************************************************************************** From: Eric Nelson Date: Fri, 10 Jan 1997 13:35:09 -0500 Subject: Does anyone know a good RRKM program?? Organization: Purdue University I'm looking for a program to calculate RRKM statistics for mass spec reactions. I find several on the web that give you the rate from the theromchemical parameters, but I'd like to go the other way and get the reaction barrier from the rate of reaction (which we can measure). Does anyone know of such a program?? ****************************************************************************** From: lippy@UVic.CA (D.Lippert) Date: Sat, 11 Jan 1997 22:23:24 GMT Subject: 204 contaminant Organization: UVic Micro-Sequencing Center I have a question concerning a possible contaminant in a sample analyzed by ESI. We know that the sample contains a biologically active peptide. However, ESI of this material shows no peptide peaks, instead we see a series of peaks which are all multiples of 204 (204, 408, 613, and 817). CID data of the larger peaks shows that they all collapse to 204, and the 204 peak fragments to give 187, 169, 158, and 145. Does anyone recognize this pattern? Could it be a membrane lipid or a plasticizer? If we knew what it was we could try removing it with chromatography, but as it stands, we can only guess as to what techniques may work. Thanks in advance for any answers. Dustin ****************************************************************************** From: Valentin <@chemistry.gatech.edu,@nac.no:Shironosov@ikar.udm.ru> Date: Sun, 12 Jan 1997 19:40:25 +0400 Subject: NEW resonance technologies and LEVITATION.(very long article) Organization: Scientific-Research Center "IKAR" NEW resonance technologies and LEVITATION. Shironosov V.G I. Levitation... it is very simple! (popular) II. New resonance technologies. III. Resonant confinement of bodies and particles (from elementary up to macro) in inhomogeneous electromagnetic fields without any external feedback. (for the specialists) I. LEVITATION... IT IS VERY SIMPLE! Such, indeed , is the case in science. First we think that it cannot be! Then... yes, it is possible. Finally we come to a conclusion: it is obvious, it is simple. The temple of charm ( a mechanical, optical and physical study of the well-known Russian illusions creator Gamuletsky which has existed up to 1942 ) was famous for its staircase. Going upstairs the visitors could see from the very below a gold angel's figure levitated in the air without any support. It was as big as a human being. When coming up you could see Seraphim lifting a French horn to his lips and playing it. His fingers moved as if he was a real person. According to Gamuletsky's notes 10 years had been spent on searching of the 'supporting' point i.e. for the location and weight of the magnet for the figure to be kept in the air. Most likely Gamuletsky felt that there were deep inner relations of the world with the cut-and-try method, errors and calculations. He made a break-down into the unknown. But further recommendations for the wonder to be made had not been left. In their turn Orthodox Moslems believe that a coffin with the Prophet's body is hanging in the air without any support. As Euler wrote it was said that Mahomet's coffin was being supported by the force of the magnet (p.159, (1) ). Is it possible or not? Perelman considers it to be impossible. If thanks to the magnetic attraction the similar equilibrium was observed even for a moment the slightest blow of the wind would be enough it - and then the coffin would fall down on the floor or would be tightened to the ceiling. To keep it motionless is practically impossible. It can be compared with a cone standing on its top. Though from the theoretical point of view it is quite acceptable (p.159, (2) ). Different reports on levitation of the subjects in the localized area are often perceived as something pseudo-scientific. Eventually the phenomenon was called - levitation. The encyclopedia explains it as " a rising of the body up to the air without any mechanism". But there is no scientific explanation to this phenomenon yet. Probably it is impossible to do this on the basis of the concepts and approaches that exist in physics. But we should not be satisfied with the ancient equivalent which explains levitation as " a supernatural ability to become light whenever we need , at our will ". The concept mixes everything up: legends, myths, and all surprising facts. Actually, everything is much easier. There is no prophet in Motherland. As early as last century Peter Lebedev, Russian scientist, described resonance as the most characteristic phenomenon in the nature. In engineering and machinery resonance was diligently bypassed. Until now in the school textbooks an example on resonance (a bridge has fallen down because of the soldiers platoon marching , though the military instructions say that bridges should be passed along in a free step ) is given in the very ordinary way. Resonance can be explained in different ways. Two events took place at one and the same time: A team of the foreign scientists of three persons in 1989 was rewarded with the Nobel Prize for the non-resonant levitation of the charged particles in the electronic traps without feedback. Resonance levitation continued to consider impossible. A team of the Russian scientists of three persons has proved theoretically and experimentally (for macro-body) the possibility of resonant confinement of bodies and particles (from elementary up to macro ) in inhomogeneous electromagnetic fields without any external feedback ( Letters to JTP, JPT, RAS USSR, 1983). The idea itself was suggested as early as in 1972 (Filatov A.I.). As it had happened many times in our country the work of the scientists has not been noticed. From both theoretical and experimental points of view a break-down has been made and the bases for the new technologies have been laid. The possibility of the resonant selective hanging up of the bodies and particles in the inhomogeneous electromagnetic fields without any external feedback has been demonstrated. For the non-professionals: such small subjects as "pens and pencils" were levitating without any support inside the installation in the course of the experiment. The foundations for the new resonance technologies have been laid by Lebedev (1890) and those experiments. It was the basis for the great improvement of the economy. As a result in 1989 that research 'was rewarded'. The scientific subdivision was excluded from the Academy of Sciences as if "it was not working effectively". A bridge between the science and the budget was broken. A great improvement turned out to be a defeat. A flight appeared to be a fall. It is very difficult to survive, but we must not betray our Motherland. It is a sin. The first ready to fly will be the winner. For the resonance tech need to have the wings - this is the reason why the Scientific-Research Center "IKAR" was born. The international information system on resonance technologies with the electron carriers will serve to reach the aim. "MIS - RT" is supposed to be produced in SRC "IKAR" in Izhevsk. Resonance was called " the most characteristic state for the nature by Lebedev, a russian scientist. According to the latest data it is a very stable state, probably, the most one. History is a witness to this: as long as a man had not tried to interfere in the earth's processes there were no disasters on Earth. By now a man has been lost in serious diseases. Our body consists of the synchronous frame of the ordered resonant - interacting molecules. Each cell has a clock which strikes the time. In case if one or another cell dies or does not react correctly the whole body will start suffering. Sometimes it leads to death. The very same processes take place in a human society. It looks as if in Russia a chain reaction has started its work. Tens of streams used resonance technologies are pulsing in many regions of the country: laser; resonance mechanisms, tools, flying machines, conveyers considering their high quality technical parameters they differ from those we have now; new systems of activation of liquid medium which allow consumption of energy to be much reduced - e.g. when purifying water to have it free from chlorine, dioxine or when intensifying the technological processes in agriculture , food production, building construction, e so on; unique high effective installations with low energy and non-contact influence where the resonance effect is used to treat and prevent different kinds of diseases. II. New resonance technologies By now it is possible to recognize the most promising directions in the area of resonance technologies: -development of resonant traps for the particles of different types and size (from elementary up to macro) without an external feedback; investigation of properties and dynamics of the certain particles in the traps (including electrons, atoms and molecules with their further packing on a board - this is a molecular technology); development of resonant traps where plasma is to be used; self - confinement plasma; -development of the new non-contact methods for prophylactics, treatment and diagnostics on the basis of effect of resonant fields on biological systems; biochemical reaction control; -selective separation of different kinds of powders (magnetic, ferromagnetic, abrasive etc.) for magnetic information carriers (magnetic disks, tapes) in particular; -new resonant supersensitive sensors of the fields (electromagnetic, acoustic, hydrodynamic, seismic, gravitational); -robotization i.e. spatial non-contact orientation, confinement and controlling of microparts when assembling systems, instruments and devices; -weighing, confinement and movement of bodies (engine rotors, toys, transport where a magnetic suspension is used). III. Resonant confinement of bodies and particles (from elementary up to macro ) in inhomogeneous electromagnetic fields without any external feedback. P.S. (for the specialists): Impossibility of levitation is usually based on the strict statement (Braunbec) that it is impossible to build up a stable configuration using non-conducting charged or magnetized bodies (Irnshow's theorem) in a medium with dielectric permittivity or magnetic permeability higher or equal to 1. It occurs due to the following fact: there are the only special points so called 'saddle points' for the potential energy of any body in the static field (electrical, magnetic, gravitational...) with no sources of the field in the area of weighing i.e. there are no stable 'pits' where a body can be settled. In one direction the body will correspondingly be involved into the area of weighing and in the other one it will be pushed out. But what is forbidden in statics may turn out to be allowed in dynamics ( in the variable fields when the bodies are moving themselves ). Perhaps the first statement of this could have been seen in Mathieu's work (1838 ) devoted to the problem of the diaphragm vibration. It turned out to be that in the corresponding equation (Mathieu's one): .. X +(h+2e*cos(2*Z))*X=0 (1) where X = dX / dz , z = w * t, w is frequency of vibration ,a dynamic stability of the unstable state in statics ( h<0 ) out of the resonance area had simultaneously been assumed and described. An example of this is a dynamic stability of the inverted pendulum with a vibrating point of a support described by ( 1 ) at small angles of its deviation from a vertical. Simple reasonings show that at large w vibration of the point of the support of the pendulum is equivalent to the appearance of the effective returning force to a vertical. When the rod of the pendulum is accelerated downwards the angle X decreases by X1 accordingly a deviating moment of the forces decreases when the rod keeps on moving up. As a consequence, the angle ( X-X1 ) will increase only by X2 Date: Mon, 13 Jan 1997 12:32:17 +1000 Subject: Re: 204 contaminant Organization: Monash University D.Lippert wrote: } } I have a question concerning a possible contaminant in a sample } analyzed by ESI. We know that the sample contains a biologically } active peptide. However, ESI of this material shows no peptide peaks, } instead we see a series of peaks which are all multiples of 204 (204, } 408, 613, and 817). CID data of the larger peaks shows that they all } collapse to 204, and the 204 peak fragments to give 187, 169, 158, and } 145. Does anyone recognize this pattern? Could it be a membrane } lipid or a plasticizer? If we knew what it was we could try removing } it with chromatography, but as it stands, we can only guess as to what } techniques may work. Thanks in advance for any answers. } } Dustin Dear Dustin, Can you give us some idea of the conditions that you are measuring under? Also what id the nature of the sample, is the peptide synthetically produced or isolated etc? Their is a fair chance it is a buffer salt of some sort. Cheers Stuart Thomson. ****************************************************************************** From: Jo Rita Jordan <76150.2171@CompuServe.COM> Date: 13 Jan 1997 14:52:10 GMT Subject: Shimadzu web site scam Organization: Analytical Consumer Analytical Chemists: There appears to be a fake message on an anonymous Web site -- and on the search engines! -- about Shimadzu and Kratos. It could be from a competitor or from a disgruntled user. Pay no attention to anonymous information! I also got two anonymous letters pointing out the site -- one may have been sent out by one of those spamming services. This is a new way the Web can be dangerous. Anonymous libel. Be on your toes! Pass the word. Jo Rita Jordan, Editor and Publisher Analytical Consumer ****************************************************************************** From: cody@jeol.com (Chip Cody) Subject: Re: MS Simulation Program Organization: JEOL USA, Inc. Date: Mon, 13 Jan 1997 17:32:30 GMT In <5b5r1r$3d3@acmex.gatech.edu> "G. Wolmershaeuser" writes: }[This is forwarded from sci.chemistry.analytical. Dr. Wolmershaeuser has }found two programs that simulate mass spectra, but needs something more }talented and powerful. DB] }I am looking for a good and versatile simulation program for mass }spectra. PD or shareware for UNIX or WINDOWS(NT or 95) platorm }preferred! Any idea? }Thanks a lot in advance }-- }G. Wolmershaeuser }FB Chemie, Univ. Kaiserslautern }wolmersh@chemie.uni-kl.de What kind of simulation are you looking for ? If the intention is to calculate fragments from a known structure, see my reply to Ian Laubscher in this news group ("Software to Interpret Mass Spectrum from First Principles"). Are you looking for teaching software, or research software ? I would suggest Kermit Murray's MS page as the best central location for MS resources on the Internet: http://tswww.cc.emory.edu/~kmurray/mslist.html Good luck with your search, and please let us know what programs you find most helpful! -- ========================================================================= |____________ |_ Robert B. Cody, Ph.D |________________________________ Applications Manager |__ Mass Spectrometry |________________________ JEOL USA, Inc. |_ |__________ http://www.jeol.com |_ e-mail: cody@jeol.com ========================================================================= ****************************************************************************** From: Iris Klaiber Date: Mon, 13 Jan 1997 22:25:26 +0100 Subject: 3-Hydroxy-palmiticacid Organization: CC University of Hohenheim (not responsible for contents) We are searching for 3-Hydroxy-palmiticacid (or another 3-Hydroxy-fatty- acid) as reference component to determine the configuration of our isolated one, which we have only in a very small amount. Does anyone have a method, or a reference to a method, for the determination of the configuration (R or S) with an maximum of 0.3 mg? Thanks in advance for any answers. Iris _______________________________________________________________ Iris Klaiber email: klaib130@uni-hohenheim.de University of Hohenheim Tel.: ++49-711-459-2248 Dep. for Chemistry Fax.: ++49-711-459-2951 Garbenstr. 30 70599 Stuttgart Germany ______________________________________________________________ ****************************************************************************** From: eri@mindlink.bc.ca (Elemental Research Inc.) Date: Tue, 14 Jan 1997 19:07:10 GMT Subject: Environmental chemistry position available at ICP-MS lab Organization: MIND LINK! - British Columbia, Canada Elemental Research Inc. of North Vancouver, British Columbia is a research/environmental/materials science laboratory specialising primarily in ICP mass spectrometry. We have a job opening for a project chemist trainee in the environmental chemistry section of the laboratory. The new person would start out in an entry level position, receive training in the instrumentation and lab procedures used at ERI, and progress to a project chemist position where he/she would be responsible for all the data for particular clients/projects. Applicants should have some experience in mass spectrometry, preferably ICP mass spectrometry, and in environmental chemistry; e.g. in ion chromatography and standard water parameters. Salary would depend on qualifications and experience. Elemental Research Inc. is one of the most respected ICP mass spectrometry labs in the world. It is located in a desirable suburb of Vancouver, Canada, which is one of the most beautiful and sought after cities in the world in which to live. Fax or email resumes to: David Gray Lab Manager Elemental Research 309-267 West Esplanade North Vancouver, B.C. Canada V7M 1A5 Tel: (604) 986-0445 Fax: (604) 986-0071 Email: eri@mindlink.bc.ca Web site: www.eri-icpms.com ****************************************************************************** From: Christopher Kaine Date: Tue, 14 Jan 1997 20:25:00 -0800 Subject: Thank-you Finngan Customers Organization: OneNet Communications HUB News Server Finngan Customers: It has been my pleasure to assist and train some of you during my 8 year tenure with Finnigan. It is Finnigan management's plan that my and other educated/trained and experienced mass-spectroscopist Technical Specialist's services are no longer required for the customers or Service Engineers. I will though, continue to avail myself to this newsgroup to offer what ever expertise I may. Again, I thank-you and wish you all the best in the coming years. Cordially; Christopher J. Kaine ex-Finnigan Technical Specialist ****************************************************************************** From: "Karl J. Treier of UniTech" Date: 15 Jan 1997 14:58:05 GMT Subject: Teknivent Where are you ? Organization: UniTech I was trying to reach the Teknivent website and it appears to have gone. Has the company ? -- UniTech 680 Northland Boulevard Suite 9 Cincinnati OH 45240, USA Phone: 1-800-989-0144 / (513) 825-0144 Fax: (513) 825-0163 E-Mail: info@uni-tech.com Web site: http://www.uni-tech.com ****************************************************************************** From: Christopher Kaine Date: Wed, 15 Jan 1997 19:40:33 -0800 Subject: Re: Thank-you Finngan Customers Organization: OneNet Communications HUB News Server Christopher Kaine wrote: } } Finngan Customers: } } It has been my pleasure to assist and train some of you during my 8 year } tenure with Finnigan. It is Finnigan management's plan that my and other } educated/trained and experienced mass-spectroscopist Technical } Specialist's services are no longer required for the customers or Service } Engineers. I will though, continue to avail myself to this newsgroup to } offer what ever expertise I may. } } Again, I thank-you and wish you all the best in the coming years. } } Cordially; } } Christopher J. Kaine } ex-Finnigan Technical Specialist Sorry, my typing leaves something to be desired. Should be Finnigan ****************************************************************************** From: kd4wyn@emi.net Date: 16 Jan 1997 14:17:26 GMT Subject: FT-IR & Epoxy - HELP Organization: The EmiNet Domain (407)731-0222 Does FT-IR comparasion really give an accurate "fingerprint" of a material such as a two component epoxy such that the FT-IR results could be used as a stand alone quality verification of the material? Example: We identify a specific batch of coating that has the desired properties we want a manufacturer to reproduce from batch to batch. We have the initial batch "fingerprinted" by FT-IR and use that spectra as the "master fingerprint" to which all subsequent batches are examined by FT-IR and compared to the master. If the spectra is "reasonably identical", does that alone assure us that the coating is really the same as the master batch? Are there other lab tests that would give us a higher degree of confidence? Thank you very much! Michael Crapps Corporate Quality Assurance Manager S.G. Pinney & Associates, Inc. Port St. Lucie, FL ****************************************************************************** From: John Callahan Date: Thu, 16 Jan 1997 11:17:48 -0500 Subject: Re: Teknivent Where are you ? Organization: Code 6113/Naval Research Laboratory Karl J. Treier of UniTech wrote: } } I was trying to reach the Teknivent website and it appears to have gone. } Has the company ? } Teknivent has been acquired by ProLab resources. They can be reached at: ProLab Resources, Inc. prolab@ix.netcom.com http://www.prolab.com (608) 278-0002 (608) 278-0072 FAX -- John H. Callahan Code 6113/Analytical Chemistry Section Naval Research Laboratory Washington, D.C. 20375 202-767-0719 FAX 202-404-8119 John.Callahan@nrl.navy.mil http://chem1.nrl.navy.mil/analytical ****************************************************************************** From: Chad Nelson Date: Thu, 16 Jan 1997 16:56:15 -0500 Subject: Re: FT-IR & Epoxy - HELP Organization: Advanced Fuel Research, Inc. kd4wyn@emi.net wrote: } } Does FT-IR comparasion really give an accurate "fingerprint" of a material } such as a two component epoxy such that the FT-IR results could be used as } a stand alone quality verification of the material? } } Example: } We identify a specific batch of coating that has the desired properties we } want a manufacturer to reproduce from batch to batch. We have the initial } batch "fingerprinted" by FT-IR and use that spectra as the "master } fingerprint" to which all subsequent batches are examined by FT-IR and } compared to the master. If the spectra is "reasonably identical", does } that alone assure us that the coating is really the same as the master } batch? Are there other lab tests that would give us a higher degree of } confidence? } } Thank you very much! } } Michael Crapps } Corporate Quality Assurance Manager } S.G. Pinney & Associates, Inc. } Port St. Lucie, FL FT-IR can give you very reproducible information regarding the chemistry of the batch (ie relative concentration of molcular species or covalent bonds/functional groups) but will not tell you how well the coating is bonded or what the structural properties of the material are. -- Sincerely, Chad Nelson Advanced Fuel Research, Inc. 87 Church Street East Hartford, CT 06108-3742 "The views expressed above are those of the author and do not necessarily reflect the views of Advanced Fuel Research, Inc. or any affiliates." ****************************************************************************** From: Paul Slater Date: Fri, 17 Jan 1997 12:27:28 0000 Subject: Electrospray research in Australia Organization: University of Wales Swansea Dear sir/madam, My name is Paul Slater, and I am currently completing my Ph.D. in novel applications of electrospray mass spectrometry. My main area of interest is in the use of organic adducts to improve the quality of salt contaminated spectra and to quantify the number of polar groups, (for example, sulfonates), that are present. I have achieved this goal with a wide range of complex polysulfonated compounds, mainly azo dyes. In October my partner and I will be moving to Australia for approximately one year. During this period I hope to find work or research in my field. I would be grateful if you could therefore advise me on some contacts whom I can approach and arrange a possible visit. Thank you in advance for your time and help. With very best wishes, Paul Slater EPSRC National Mass Spectrometry Service Centre, Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea SA2 8PP. U.K. ****************************************************************************** From: J K Brandau Date: Fri, 17 Jan 97 09:19:27 PST Subject: Losing GC column pressure Organization: * Our Varian 3400CX gas chromatograph coupled to out Saturn 3 GC/MS has a 1077 Split/Splitless injector. After a BTEX run on the Tekmar 2016 autosampler, the backpressure gauge on the GC went to zero! We notice when tripping the GC into run mode, the pressure returns. The pressure is lost again when GC returns to ready mode. We are having a difficult time identifying the problem. Has anyone had a similar problem? Thanks, Ken Brandau ------------------------------------- Name: J K Brandau E-mail: J K Brandau Date: 1/17/97 Time: 9:19:27 AM This message was sent by Chameleon ------------------------------------- ****************************************************************************** From: Eric Nordstrom Date: Sat, 18 Jan 1997 00:28:00 -0800 Subject: Nondestructive Oriented Website Organization: Micron Internet Services To whom it may concern, My name is Eric Nordstrom. I am a Nondestructive Inspection Specialist within the U.S. Air Force. This note is designed to notify individuals within the Nondestructive Community that I have a homepage posted designed to allow easy access to hard-to-find information, other web sites, newsgroups, and employment all Nondestructive Oriented. Please pay a visit to "http://netnow.micron.net/~dozod/". Send me comments and suggestions via: dozod@micron.net. Thank you, E.G.Nordstrom ****************************************************************************** From: "Rick Flurer" Date: 19 Jan 1997 04:02:01 GMT Subject: Re: rat poison Organization: home Brodifacoum can be detected quite nicely by positive ion APCI using an acetonitrile/water gradient. Use a C18 column and add 0.1 % formic acid to moble phase to suppress ionization of the acidic enol group. Tandem MS on MH+ ion is quite useful for i.d. proof. regards, rick flurer phil harris wrote in article <59e6q3$c34@acmey.gatech.edu>... } Im trying to set up an LC-MS method for the analysis of a rat poison } (brodifacoum) but have found that in ESI the chromatogram is inverted ie } the analyte apparently suppresses the background ion current. The } effect is the same in positive and negative mode, and I havent tried } APCI yet to see if the effect is the same. Is there a way around this } to get my chromatograms the right way up?! } } } } } ****************************************************************************** From: mrdio007@aol.com (MrDio007) Date: 19 Jan 1997 18:32:49 GMT Subject: Re: 3-Hydroxy-palmiticacid Organization: AOL http://www.aol.com In the process of investigating the fatty acid synthesis pathway of bacteria I was forced to synthesize 3-Hydroxy-Decynoyl NAC(ie you might not be able to buy it) I am pretty sure that the enzyme pathways are stereospecific for one isomer over another. The Cycle of FA synthesis produces the 3-0H configuration . This is stereospecific in E.Coli (and most others I'd imagine)Because the subsequent step in which the 3-OH form is utilized has a stereospecific requirement. I Quote; Beta-Ketoacyl-ACP reductase The reaction product of acetoacetyl-ACP has the D(-) configuration. Beta-Hydroxyacyl-ACP dehydrasae The enzyme (beta-hydroxyacyl-ACP dehydrase) catalyses the dehydration of D(-)-beta-hydroxyacyl-ACP thioesters to form trans-2-enoyl-ACP thioesters... Like the beta-ketoacyl-ACP synthetase, the dehydrase has an absolute specificity for thioesters of ACP; it is inactive with thioesters of CoA or pantetheine. The reaction is stereospecific; the D(-) isomer of beta-hydroxybutryl-ACP was dehydrated whereas the L(+) isomer was not. pg 123 Quotes from Biochemistry of Lipids Ed. TW Goodwin, F.R.S. Vol. 4 of the MTP International Review of Science Series 1974 ISBN 0-8391-1043-X Butterworth and Co. Pub. You might also check out Morris Kates' "techniques of lipidology" Elsevier (2nd ed 1986) This guy is the GOD of lipids in my opinion. he says on pg 34 "The b-hydroxy saturated acids form a series of even-carbon acids...3-Hydroxy acids are fairly widespread in yeasts and bacteria, usually occuring as D(-) isomers in ester bound or glycosidic forms in extracellular lipids. For example, 3-D-OH-C10,-C12,-C14 acids are constituents of lippopolysaccharides in cell walls of Gram-Negative Bacteria (Kaneshiro & Marr 1963 Biochim.Biophys.Acta, 70,271); 3-D-hydroxy-C10 acid occurs in the rhamno-lipid of Pseudomonas aeruginosa (Jarvis and Johnson 1949, JACS, 71,4124)...(another ref...Tulloch and Spencer1964, Can.J.Chem.42,830)..The D-3-OH acids are also intermediates in the beta-oxidation pathway of fatty acids." Many people (eg. Julie Leary et al) have been using the addition of Metals to differentiate various types of isomers using mass spec. If you have some standards in D and L forms and you have a mass spec you could develop a method. Otherwise maybe one of the old papers have methods (bucket loads of sample ?) Source of the material combined with literature info may tell you indirectly the D/L of what you have. John Cronan is another awesome lipid guy (U Ill ?) good luck Matt Sweeney good luck ****************************************************************************** From: mrdio007@aol.com (MrDio007) Date: 19 Jan 1997 18:42:18 GMT Subject: Re: 204 contaminant Organization: AOL http://www.aol.com You might try putting it on a column and seeing what the chromatographic profile of the contaminant versus the peptide is. It'd give you some clues. It'd also get the peptide away form the garbage. (a guess >>> Mannitol/Inositol +Na = 203.2 ?) ****************************************************************************** From: adamf@vtaix.cc.vt.edu (Adam Finkelstein) Date: 20 Jan 1997 17:02:37 GMT Subject: FID with Shimadzu GC14A --Sensitivity problems Organization: Virginia Tech Hello. I'm using a Shimadzu GC 14A with FID and an RTX 5 capillary column. I have optimized all my parameters and have checked with Shimadzu and they concur. They sent me very arcane instructions on cleaning the detector. I am planning to replace the nozzle, but would like to avoid cleaning the detector if possible: it seems very detailed and laborious. Has anyone cleaned an FID detector like this? If so would you mail or post about your experience? thanks! Adam -- _________________ Adam Finkelstein adamf@vtaix.cc.vt.edu http://sunsite.unc.edu/bees/adamf/home.html ****************************************************************************** From: Corinne Bure Date: Mon, 20 Jan 1997 20:48:46 +0100 Subject: Patchouly's component Organization: Grolier Interactive Europe I m an student in Spectrochemistry and my subject's trainee is the study of an Essential Oil of Patchouly by Mass Spectrometry coupled with gas chromatography. So, I search for mass spectra of the Patchouly oil like ... - Patchoulenone M=218 C15 H22 O - Isopatchoulenone M=218 C15 H22 O - Norpatchoulenol M=206 C14 H2 O - Pogostol M=222 C15 H26 O - 1 alpha - 5 alpha Epoxy - alpha Guaiene M=220 C15 H24 O - 1 beta - 5 beta Epoxy - alpha Guaiene M=220 C15 H24 O - 1,10 Epoxy alpha Bulnesene M=220 C15 H24 O - alpha Patchoulone M=220 C15 H24 O - beta Patchoulone M=220 C15 H24 O - 5 oxo Patchoulol M=236 C15 H24 O2 - alpha Guaienone M=218 C15 H22 O - alpha Cedrenal M=218 C15 H22 O - beta Patchoulenone M=218 C15 H22 O - gamma Selinene ? - Pogostone M=224 C12 H16 O4 - alpha Elemene M=204 C15 H24 - Beta Bulnesene M=204 C15 H24 Thank you for your help. ****************************************************************************** From: SCROOD Date: Mon, 20 Jan 1997 14:19:31 +0000 Subject: amine analysis Organization: Animal Sciences, Univ. of Illinois has anyone had any luck with amine analysis using mass spec? any advice would be appreciated. pete ****************************************************************************** From: gbird@superlink.net Date: Tue, 21 Jan 1997 00:55:22 GMT Subject: Re: amine analysis Organization: SuperNet Inc. (908) 828-8988 On 20 Jan 1997 15:29:27 -0500, SCROOD wrote: }has anyone had any luck with amine analysis }using mass spec? } }any advice would be appreciated. } } }pete Sure I have Pete, what kind of amines are you looking at? } ****************************************************************************** From: SCROOD Date: Tue, 21 Jan 1997 08:59:11 +0000 Subject: Re: amine analysis Organization: Animal Sciences, Univ. of Illinois gbird@superlink.net wrote: } } On 20 Jan 1997 15:29:27 -0500, SCROOD } wrote: } } }has anyone had any luck with amine analysis } }using mass spec? } } } }any advice would be appreciated. } } } } } }pete } } Sure I have Pete, what kind of amines are you looking at? } } } i don't know i need a little advice on sample prep. (pH...etc.) and the proper column and column temp. does this help? pete ****************************************************************************** From: Ian Michael Date: Tue, 21 Jan 1997 15:22:33 +0000 Subject: European Mass Spectrometry Issue 2/6 Organization: IM Publications Distribution: world The complete abstracts of issue 2/6 of European Mass Spectrometry are now available on our web site: http://www.impub.co.uk These abstracts and those of all previously published issues are searchable. If anyone cannot access the WWW and would like a text version e-mailed to them, please send a message to me. -- Ian Michael IM Publications Publishers of: 6 Charlton Mill European Mass Spectrometry Charlton Spectroscopy Europe Chichester Journal of Near Infrared Spectroscopy West Sussex PO18 0HY NIR news United Kingdom Tel: +44-1243-811334 Fax: +44-1243-811711 E-mail: ian.michael@impub.demon.co.uk Web site: http://www.impub.co.uk ****************************************************************************** From: dmichaud@phy.ulaval.ca Date: 21 Jan 1997 18:43:29 GMT Subject: tmpump grease Organization: Universite Laval Distribution: world Do there exist alternate suppliers of ball bearing grease for Alcatel turbomolecular pumps? We are finding out how costy the syringe refills are... Thank you, Daniel Michaud Departement de physique Universite Laval ****************************************************************************** From: "Joe Bumgarner, Jr." Date: Tue, 21 Jan 1997 13:52:28 -0500 Subject: Re: Teknivent Where are you ? Organization: SciQuest Karl J. Treier of UniTech wrote: } } I was trying to reach the Teknivent website and it appears to have gone. } Has the company ? } } -- } UniTech } 680 Northland Boulevard } Suite 9 } Cincinnati } OH 45240, USA } } Phone: 1-800-989-0144 / (513) 825-0144 } Fax: (513) 825-0163 } E-Mail: info@uni-tech.com } Web site: http://www.uni-tech.com I found this company information, TEKNIVENT CORP., MARYLAND HEIGHTS, MO at SciQuest (http://sciquest.com). You can send them a email directly from the web site. Good Luck, ____________________________________________________________________ Joe Bumgarner, Jr. SciQuest - "Internet Solutions for Science" jbumgarner@sciquest.com "http://sciquest.com" Site Director Phone: 919-732-5813 FAX: 919-782-3123 ____________________________________________________________________ ****************************************************************************** From: Chris Elhardt Date: 21 Jan 1997 22:48:33 GMT Subject: Re: Losing GC column pressure Organization: Texas Department of Health You should have a septum purge restriction in the system; sounds like it could be either missing (if you have the fixed restrictor) or wide open (if you have the valved restrictor) a) fixed restriction: Look for a nickel line from the injector block terminating in a brass union. The union may be painted either green or blue depending on the restriction. Make sure the restriction is present and tightened. b) variable restriction: Look for a vernier to the right of the injector (there may be a pair of them if you have both split/splitless and a SPI injector installed. ) Measure the flow at the valve; should be about 1 ml/min/pound of head pressure; adjust accordingly. c) check your gc program in the analysis-page/gc edit. select the set parameter menu item and make sure that you've got your relays the way you want them. sounds like you may be switching to split during desorb and splitless during the run. Also check that the quarter-inch graphite seal around the injector liner is undamaged. It's only good for about 4-5 liners and then should be replaced. chris J K Brandau wrote: }Our Varian 3400CX gas chromatograph coupled to out Saturn 3 GC/MS has a }1077 Split/Splitless injector. } }After a BTEX run on the Tekmar 2016 autosampler, the backpressure gauge on }the GC went to zero! } }We notice when tripping the GC into run mode, the pressure returns. The }pressure is lost again when GC returns to ready mode. } }We are having a difficult time identifying the problem. Has anyone had a }similar problem? } }Thanks, } }Ken Brandau }------------------------------------- }Name: J K Brandau }E-mail: J K Brandau }Date: 1/17/97 }Time: 9:19:27 AM } }This message was sent by Chameleon }------------------------------------- } } } ****************************************************************************** From: charland Date: Wed, 22 Jan 1997 22:12:06 GMT Subject: compound type distribution from HP GC/MS chemstation software library search listing Organization: Natural Resources Canada (NRCan) The library search routine from the HP chemstation software driving an HP GC-MSD system produces an output listing with hits for each chromatogram peak using the mass spectrum collected at that retention time. This provides useful data but does not allow you to have an overall compound type distribution or I should say a way of classifying the best hits according to their chemical type, i.e., ketones, aromatics, carboxylic acids, paraffin, etc. Anybody heard of some software that would use such output listing to classify compounds into organic types and provide an overall type distribution? This could be useful if you are to look at and assess various types of oils like petroleum crudes, derived oil fractions or pyrolysis oils. I Hope this will attract some comments and feedback. Thank you ****************************************************************************** From: plaut@sc2a.unige.ch (Olivier PLAUT) Date: Thu, 23 Jan 1997 10:18:42 +0200 Subject: Re: compound type distribution from HP GC/MS chemstation software Organization: University of Geneva, Switzerland In article <5c5pc5$fjk@acmex.gatech.edu>, charland writes: } The library search routine from the HP chemstation software } driving an HP GC-MSD system produces an output listing } with hits for each chromatogram peak using the mass spectrum } collected at that retention time. This provides useful data } but does not allow you to have an overall compound type distribution } or I should say a way of classifying the best hits according to their } chemical type, i.e., ketones, aromatics, carboxylic acids, } paraffin, etc. Anybody heard of some software that would use } such output listing to classify compounds into organic types } and provide an overall type distribution? This could be useful } if you are to look at and assess various types of oils like } petroleum crudes, derived oil fractions or pyrolysis oils. } } I Hope this will attract some comments and feedback. } Thank you } In the libraries, you have a "Misc information" field. If you have your own library, you can put in the chemical type and then modify the PBM macro to get selected type answers only. Of course, if you want to modify a very large existing library, it is a hard work. Olivier -- ------------------------------------------------------------------- Olivier Plaut | Institute of Forensic Medicine | Phone: +41 (22) 702.56.09 Toxicology Unit | Fax: +41 (22) 789.24.17 University of Geneva | Av. de Champel 9 | E-mail: plaut@sc2a.unige.ch CH-1211 Geneve 4 | Switzerland | ------------------------------------------------------------------- ****************************************************************************** From: "Lewis K. Pannell" Date: Thu, 23 Jan 1997 12:21:57 EST Subject: Post Doctoral Appointment Available in NIDDK, NIH Organization: * The Structural Mass Spectrometry group at NIDDK, NIH, has an opening available for a post doctoral candidate. Work will largely concentrate on mass spectrometry as applied to biopolymers but the laboratory also does a large amount of structural identification on smaller compounds with potent specific biological activity. Please refer to http://sx102a.niddk.nih.gov/lewisjob.html for more information. -- Dr. LEWIS K. PANNELL Bldg 8, Rm B2A23, LBC, NIDDK National Institutes of Health Bethesda, MD 20892-0805, USA. Ph (301)402-2196 FAX (301)402-1967 Email: L_Pannell@nih.gov ****************************************************************************** From: phil harris Date: 24 Jan 1997 05:02:49 GMT Subject: rat poison again Organization: Biomedical Mass Spec Unit, UNSW, Sydney In a reply to my previous query, someone responded with reference to/experience of APCI in the study of brodifacoum, but I couldn't contact them to find out more. I'd be grateful if he could contact me and/or let me know if the work has been published. Thanks in advance. ****************************************************************************** From: "Lee, Ji Hyun" Date: Fri, 24 Jan 1997 14:08:39 +0900 Subject: MALDI-TOF is suitable to identify whether a protein is a dimer or a trimer? Organization: College of Pharmacy, Seoul National University MALDI-TOF analysis is suitable to identifying whether a protein is a homodimer or a homotrimer? I have a small DNA-binding protein(6,100 dalton) quite well purified. Through size exclusion HPLC gel chromatography, I found its effective molecular weight of the protein in the absence of its binding DNA sequence is about 19,000 dalton, close to homotrimer. But I am not sure that it is a trimer based on only the result becuase I didn't ever hear about homotrimer DNA binding protein; so I need some additional experiments confirming this fact. Thank you for your time and expertise, Lee, Ji Hyun ****************************************************************************** From: heino.prinz@mpi-dortmund.mpg.de (Heino Prinz) Date: Fri, 24 Jan 1997 14:47:35 GMT Subject: Re: MALDI-TOF is suitable to identify whether a protein is a dimer or a trimer? Organization: MPI-Dortmund On 24 Jan 1997 08:13:51 -0500, "Lee, Ji Hyun" wrote: }MALDI-TOF analysis is suitable to identifying whether a protein is a }homodimer or a homotrimer? } }I have a small DNA-binding protein(6,100 dalton) quite well purified. }Through size exclusion HPLC gel chromatography, I found its effective }molecular weight of the protein in the absence of its binding DNA }sequence is about 19,000 dalton, close to homotrimer. }But I am not sure that it is a trimer based on only the result becuase I }didn't ever hear about homotrimer DNA binding protein; so I need some }additional experiments confirming this fact. } You probably should run the protein on an electrospray mass spectrometer. regards, Heino Prinz Tel.:(+49)-231-1206-332 Fax:(+49)-231-1206-389 ****************************************************************************** From: "Alex" Date: 24 Jan 1997 19:53:25 GMT Subject: Filament power supply floating at 12kV needed Organization: Swiss Federal Institute of Technology (ETHZ) Hello, Anyone ever had a problem of finding a filament power supply for the electron gun which would be capable of floating at +/-12kV and providing up to 5Amps regulated current at 0-5V? Any companies who manufacture that? Please reply to alik@erdw.ethz.ch. Alexander Likholyot -- My real email was altered to prevent junk mail. ****************************************************************************** From: sismspec@aol.com (Sismspec) Date: 26 Jan 1997 22:02:13 GMT Subject: Position Available - Scientific Product Manager Organization: AOL http://www.aol.com Position available at Scientific Instrument Services in ringoes, NJ. Scientific Product Manager to provide technical support for our MS, GC, LC, Vacuum fittings and Thermal Desorption product lines. This includes phone support with customers, attending trade shows, operating our mass spectrometers and accessory equipment to solve customer problems or provide customers with applications, and aiding in the development of new products. This person will be responsible to answer customer technical questions relating to the products we sell, repair or manufacture. This person will also help customers with the maintenance of their mass spectrometers, gas chromatographs, liquid chromatographs and other scientific instruments utilizing our parts and services and provide customer technical support. The position is at our facilities in Ringoes, NJ with minimal travel, restricted mainly to several trade shows. The second function of this position is to work as part of the SIS new product development team. This involves the development of new GC/LC/MS accessories, supplies, techniques and services which will be marketed to the scientific market. We are presently beginning the development of new LC/MS equipment and therefore a good LC background will be necessary for this position. In addition this person will develop ideas for new products and services we can market from other vendors and suppliers as well as from our own manufacturing facilities. The will evaluate new products from our distributors and incorporate them into our product line and solicit new products and dealerships. For more information, contact John Manura at (908)788-5550 or via E-Mail at sis@sisweb.com or visit our web site at http://www.sisweb.com/index/referenc/sisemplo.htm for more information. John J. Manura Scientific Instrument Services Supplies and Services for Mass Spectrometers, Gas Chromatographs and related Scientific Instruments SIS Home Page: http://www.sisweb.com E-Mail: sismspec@aol.com Phone: (908) 788-5550 FAX: (908) 806-6631 ****************************************************************************** From: Clair Bragg Date: Sun, 26 Jan 1997 18:16:13 -0800 Subject: HP 5970 Organization: GenTech Scientific, Inc. Dear HP mass spec user, We currently have a 5970 with Pascal Chem Station. We would like to sell or trade it. If you still have a need please contact GenTech Scientific at 716-631-1022. Sincerely, Clair Bragg ****************************************************************************** From: Tim Pope Date: 27 Jan 97 01:49:14 GMT Subject: hydrogen fluoride detection Organization: TotalNet Inc. I'm trying to determine [HF] gas concentration between .5ppm and 120ppm--can this be done quantitatively with a quadrapole mass spec? I'd appreciate any comments, hints or ideas! Thanks, Marci Vernon ****************************************************************************** From: Don Magin Date: Mon, 27 Jan 1997 15:01:05 -0800 Subject: Hickory flavor Organization: Whitehall-Robins Analytical Research Does anyone know of a compilation of compounds (and their mass spectra) which are typically found in hickory flavor? In a more general sense, can anyone point me toward some reference books or articles which list the compounds which might be expected to be found in flavors, oils, and perhaps other such common products such as cleaning fluids, fuels, etc. We sometimes have the occasion to try to identify such materials in adulterated or mis-handled products. ****************************************************************************** From: pggreen@cco.caltech.edu (Peter G. Green) Date: Mon, 27 Jan 97 20:42:12 GMT Subject: Job Opening Organization: Env. Eng. Sci., Caltech This Thursday, January 30th, 1997, the following announcement of a job opening will appear at Caltech's Human Resources list of employment opportunities http://www.cco.caltech.edu/~employ/posting.html at which time one may telephone them for official application information. ASSISTANT SCIENTIST Env. Eng. Science Will perform assistance in all operations of the Environmental Analysis Center (elemental and organic mass spectrometries and chromatographies). Responsibilities will include: routine maintenace; problem solving and troubleshooting; assuming full responsibility during Scientist's absences; applications of standard techniques; and instructing users and assisting researchers. Reqs. BS degree in Earth or Environmental Science or Chemistry and min. 6 mos. related exp. or equivalent. Must possess exp. with PC's (hardware, software, networking accessories, including multimedia), and general electrical and mechanical skills. Must be able to prioritize, work independently, and possess excellent interpersonal and communication skills. Candidates must submit a cover letter, resume and names of 3 references with phone numbers and/or e-mail address. ****************************************************************************** From: yamx0001@gold.tc.umn.edu Date: Mon, 27 Jan 1997 14:46:29 -0500 Subject: LDV - schematics ?? Organization: University of Minnesota I am a physics student at the U of MN. I'm developing an experiment and need to implement a Laser-Doppler Velocitometer (LDV), in order to measure the velocity of Couette-Taylor fluid flow. I only need to measure 1 dimension, and don't need anything fancy of sophisticated. Can anyone help me out with schematics for transmitting and receiving circuits, and interfacing with a PC? I have lasers. I just don't know how to design the circuits. Please post or email me would be better. Thanks. Patrick yamx0001@gold.tc.umn.edu ****************************************************************************** From: winnik@charlotte.med.nyu.edu (Witold Winnik, Ph.D.) Date: Tue, 28 Jan 1997 09:16:49 -0500 Subject: LC/GC MS/MS mass spectrometers Organization: * Hello, I am trying to find a mass spectrometer which can perform the following tasks: 1. reasonably easily switches between GC/MS and LC-electrospray jobs (one week it would perform a GC/MS analysis and following weeks LC/MS, for example) 2. capable of EI / CI and positive / negative ionization 3. performs MS and MS/MS analysis; mass range up to 3000-4000 m/z And costs below $400,000. I know that Finnigan GCQ and LCQ ion traps would qualify jointly but the problem is I can request only one instrument in my proposal, even though it would be probably less expensive to aquire both GCQ and LCQ instead of one instrument that can switch between GC and LC jobs. If anyone knows about such instrument, or has been using it please contact me at: winnik@charlotte.med.nyu.edu Witold Winnik NYU Medical Center ****************************************************************************** From: Bill Cotham Date: Tue, 28 Jan 1997 09:36:01 -0500 Subject: Re: LC/GC MS/MS mass spectrometers Organization: USC Mass Spectrometry Center Witold Winnik, Ph.D. wrote: } } Hello, } } I am trying to find a mass spectrometer which can perform the following tasks: } 1. reasonably easily switches between GC/MS and LC-electrospray jobs (one } week it would perform a GC/MS analysis and following weeks LC/MS, for } example) } 2. capable of EI / CI and positive / negative ionization } 3. performs MS and MS/MS analysis; mass range up to 3000-4000 m/z } And costs below $400,000. } } I know that Finnigan GCQ and LCQ ion traps would qualify jointly but the } problem is I can request only one instrument in my proposal, even though it } would be probably less expensive to aquire both GCQ and LCQ instead of one } instrument that can switch between GC and LC jobs. } If anyone knows about such instrument, or has been using it please contact } me at: winnik@charlotte.med.nyu.edu } } Witold Winnik } NYU Medical Center I think a Finnigan TSQ or a Micromass Quatro would meet all of your specs. -- Bill Cotham, Ph.D. Mass Spectrometry Laboratory Dept. of Chemistry and Biochemistry University of South Carolina Columbia, SC 29208 803-777-2039 (voice) 803-777-9521 (fax) ****************************************************************************** From: JGRAFF@PILLSBURY.COM Date: Tue, 28 Jan 1997 13:56:09 -0600 Subject: 5890/5970 GC/Mass Spec Organization: * I have a 5890/5970 with 2 pacal workstations for sale. If you are interested please contact me. I'm looking for approx $25000 but am willing to talk. You can E-mail me at -- jgraff@pillsbury.com. ****************************************************************************** From: ajohnson@chemistry.adelaide.edu.au (Andrew Johnson) Date: Wed, 29 Jan 1997 20:40:45 +1030 Subject: ESQUIRE User Interface Organization: The University of Adelaide Has anyone out there use the new user interface for the Bruker ESQUIRE , which is supposed to be based on HP's ChemStation HPLC software ( and looked like a VB interface to me from pix ) ? Or perhaps even compared it to a Finnigan LCQ ? ( I'm aware of the technical specifications of the respective machines, but I was curious as to the impressions from the user interfaces , and the reliability and stability of the PC based software ) -- Andrew Johnson Email: ajohnson@chemistry.adelaide.edu.au _-_|\ Dept of Chemistry Phone: +61 8 3033241 / \ The Uni of Adelaide Fax: +61 8 3034381 \_.-*_/ AUSTRALIA v ****************************************************************************** From: cgek@cc.newcastle.edu.au (E M Kennedy) Date: Thu, 30 Jan 1997 09:12:33 +1100 Subject: Kratos spares Organization: Chemical Engineering, Newcastle univ (Australia) Dear group, Does anyone have spares for Kratos MS25/80 which they are intersted in selling? Im mainly interested in spares for the source and data system. Please contact me for details Eric Kennedy cgek@cc.newcastle.edu.au Ph +61 - 49 - 21- 6177 Fax +61 - 49 - 21 -6920 Thanks ****************************************************************************** From: tswenson@ral.mindspring.com (SpectraSource) Date: Wed, 29 Jan 1997 19:59:24 -0200 Subject: WANTED: 5989A MS Engine Organization: SpectraSource, Inc. We are looking for a used 5989A MS Engine, and will pay a good price, especially if the instrument has many of the options we seek. Please respond by e-mail or call (919) 571-0940 ****************************************************************************** From: David Sparkman <75530.3472@compuserve.com> Date: Wed, 29 Jan 1997 21:43:00 -0500 Subject: Library Search Organization: * On 22 Jan, charland of Natural Resources Canada (NRCan) wrote: {The library search routine from the HP chemstation software {driving an HP GC-MSD system produces an output listing {with hits for each chromatogram peak using the mass spectrum {collected at that retention time. This provides useful data {but does not allow you to have an overall compound type distribution {or I should say a way of classifying the best hits according to their {chemical type, i.e., ketones, aromatics, carboxylic acids, {paraffin, etc. Anybody heard of some software that would use {Such output listing to classify compounds into organic types {And provide an overall type distribution? This could be useful {If you are to look at and assess various types of oils like {Petroleum crudes, derived oil fractions or pyrolysis oils. The NIST Mass Spectral Search Program for Windows offers substructure identification; which is what I think you want. The program will examine the best 100 spectra from the libray search of an unknown and determine the probablity of the presence and absences of various substructure features of the spectrum that was searched. This includes things such as aldehydes, ketones, acids, ring-plus-double-bonds, hetroatoms, aromatic nature, etc. This is what you are looking for. This program will work interactively with the HP software. You can buy it from WindChem Software in Fairfield, CA (1-800-536-0404) for $1,495 with the NIST/EPA/NIH database of about 75,000 spectra. If you already have the HP NBS75K.L database, the price is $750. Regards; O. David Sparkman Consultant-At-Large Phone: 1-510-754-5003 ****************************************************************************** From: Federico Pea Date: Thu, 30 Jan 1997 16:00:49 +0100 Subject: Tamoxifen and its metabolites Organization: Institute of Clinical Pharmacology and Toxicology - University of Udine - Italy Hi, we are looking for an HPLC-LC/MASS method to separate tamoxifen and its major metabolites. Thanks in advance -- Federico Pea, MD Institute of Clinical Pharmacology and Toxicology University of Udine P.le S.M. Misericordia, 3 33100 Udine Italy e-mail : furlanut@hydrus.cc.uniud.it web: http://www.uniud.it/ifct/welcome.html ****************************************************************************** From: "Joe Bumgarner, Jr." Date: Thu, 30 Jan 1997 16:10:07 -0500 Subject: Vendor Search/Communication Tool Organization: SciQuest To locate and communicate with vendors of virtually any scientific product or service, go to http://sciquest.com. Conduct a keyword search of our database of over 5000 vendors, then broadcast your request to all the vendor(s) that sell that product. It's completely FREE and will save you time and expand your purchasing options. Best Regards, ____________________________________________________________________ Joe Bumgarner, Jr. SciQuest - "Internet Solutions for Science" jbumgarner@sciquest.com "http://sciquest.com" Site Director Phone: 919-732-5813 FAX: 919-782-3123 ____________________________________________________________________ ****************************************************************************** From: Massimo Baraldo Date: Fri, 31 Jan 1997 12:07:55 +0100 Subject: tamoxifen metabolites (II) Organization: Cineca HELP For analytical purpose I am looking for few miligrams of tamoxifen metabolites (N-desmethyl-tamoxifen ; N,N-didesmethyl-tamoxifen; 4-OH-tamoxifen; isomers of 4-OH-tamoxifen; tamoxifen-N-oxide). Where can I found those samples or does anybody know who can synthesize them? It seems that they are not commercialy available. -- Massimo Baraldo, MD Institute of Clinical Pharmacology and Toxicology University of Udine P.le S.M. Misericordia, 3 33100 UDINE Italy e-mail: furlanut@hydrus.cc.uniud.it web: http://www.uniud.it/ifct/welcome.html ****************************************************************************** From: David Sparkman <75530.3472@compuserve.com> Date: Fri, 31 Jan 1997 09:42:39 -0500 Subject: LC-GC/MS Instrument Organization: * On Tuesday January 28 Witold Winnik, Ph.D. wrote looking for an instrument that will do EI/CI GC/MS and can be switched to ESI LC/MS. One of the best instruments for this is the Finnigan/ATI Automass built in Paris. This instrument was desiged to work along these lines. It is currently being sold by Finnigan out of Austin, Texas. O. David Sparkman Consultant-At-Large Phone: 1-510-754-5003 ****************************************************************************** From: cip1591@iperbole.bologna.it (Ermanno Errani) Subject: GC-MS of pesticides: help on general rules Date: Thu, 30 Jan 1997 21:28:27 GMT Organization: NETTuno I am interested in pesticides residues analysis in foods: every time I find something by GC-ECD or NPD, I try to confirm it by GC-MS with quadrupole (SIM), in the case I already know the mass spectrum of the hypotised compound. Otherwise, I must try to get a complete scan (total ion) for a part of the chromatogram, and watch the scan of each peak detected (finding Hydrocarbons, waxes, terpenes, acids, lots of naturally occurring compounds). The library search for matching probability often gives me very strange kind of molecules with little meaning, and the total ion scan lack the sensitivity needed for the detection of p.p.m. amounts of contaminants. I could concentrate 100- to 1000-fold the extract, with the sure result of great conyamination of liner, column, and even ion source of quadrupole. Is there a rule for monitoring groups of compounds (e.g. fungicides, phosphoric esters, halogenated compounds) by SIM of few peaks (up to 20) and with a minimum number of injections ? Thanks for every kind of suggestions ! Ermanno Errani ****************************************************************************** From: david.bostwick@chemistry.gatech.edu (David Bostwick) Date: 31 Jan 1997 16:17:02 GMT Subject: ADMIN: Computer down time Organization: Georgia Tech The computer that handles the newsgroup will be down Monday, February 3, beginning at 0400 EST, for the installation of a UPS. It should be back up by late Monday afternoon. ****************************************************************************** From: lfu@tamu.edu (Liqun Fu) Date: Fri, 31 Jan 1997 20:23:48 GMT Subject: Mass calibration and SIS Organization: Texas A&M Univ. Hi, All, Is anyone out there familiar with Mass calibration and SIS for a GC/MS system? The mass calibration is based on FC-43. The peaks at masses 69, 131, 264, 414, 464, 502 were found, but mass at 614 was not found. The slope of the calibration was 6.300 with a standard deviation of less than 0.150. With such conditions, will the SIS function properly? If not, how to correct it? The molecular weights of all the compounds which need to be analyzed are below 400 and the system works fine with EI and no SIS. Thanks in advance, Liqun Fu, Graduate assistant Soil and Crop Sciences lfu@tamu.edu Texas A&M Univ. (409) 845-7654 ****************************************************************************** From: U61985@UICVM.UIC.EDU Date: Fri, 31 Jan 1997 14:45:35 CST Subject: Matrix solutions for MALDI Organization: University of Illinois at Chicago, ADN Computer Center Can anyone tell me who sell matrix solutions for maldi? I know HP makes those solutions but I don't have their catolog. Any informations are welcome. ****************************************************************************** From: Jeffrey Craig Thomas Date: Fri, 31 Jan 1997 21:24:56 -0500 Subject: Re: Matrix solutions for MALDI Organization: iWAYnet Communications U61985@UICVM.UIC.EDU wrote: } } Can anyone tell me who sell matrix solutions for maldi? I know HP makes } those solutions but I don't have their catolog. Any informations are } welcome. HP's analytical tech support number is 1-800-424-9759 -- Jeffrey C Thomas Columbus, Ohio. USA http://www.iwaynet.net/~jcraig email: jcraig@iwaynet.net ****************************************************************************** From: "Kiley R. Prilliman" Date: Sun, 02 Feb 1997 19:28:05 -0600 Subject: HPLC-RP column selection--question! Organization: University of Oklahoma Health Sciences Center To anyone who might be able to help me out a bit: I am currently applying LC/MS to study a complex mixture of purified peptides (peptide sequences vary, as verified by fractionation and Edman sequencing, but average size is known to be 7-10mers). Currently, I have been using a 1.0 x 150mm microbore C18 column, upon which I load 100 micrograms of the peptide mixture and elute with a 30 minute gradient up to 60% acetonitrile (flow rate = 40 microliters/min). While this has proven to be a fairly good and reliable way of "mapping" the peptide mixture in a consistent manner, I would very much prefer to be able to perform the same sort of analysis but with significantly smaller amounts of my peptides (this would be nice, as the whole purification process to actually obtain the mixture is quite labor intensive...this, coupled with the fact that "ironing out" portions of my protocol has required multiple runs, many of which are useless in terms of "real" data). I have been considering "sizing down" and using a smaller column (500, 300, or 180 micron diameter). This is where my question(s) comes in: what could be the potential consequences of using a smaller column: would I be able to obtain the same type of results, or would I be sacrificing either sensitivity or resolution in doing so? If a smaller column would be a valid option for me, then what would be the recommended size to which I should scale down? Thank you for your time; I sincerely appreciate any assistance which you might be able to provide! Kiley R. Prilliman Department of Microbiology & Immunology University of Oklahoma Health Sciences Center phone: 405-271-1203 fax: 405-271-3117 ****************************************************************************** From: John Glowacki Date: 3 Feb 1997 15:59:11 GMT Subject: ICP-MS Aqueous Sn? Organization: UW-Madison I'm looking for some input on running trace level Sn analysis by ICP-MS on surface water samples. Interference equation? Thanks in advance. ****************************************************************************** From: Bill Cotham Date: Mon, 03 Feb 1997 09:24:05 -0500 Subject: Re: GC-MS of pesticides: help on general rules Organization: USC Mass Spectrometry Center Ermanno Errani wrote: } } I am interested in pesticides residues analysis in foods: every time I } find something by GC-ECD or NPD, I try to confirm it by GC-MS with } quadrupole (SIM), in the case I already know the mass spectrum of the } hypotised compound. Otherwise, I must try to get a complete scan (total } ion) for a part of the chromatogram, and watch the scan of each peak } detected (finding Hydrocarbons, waxes, terpenes, acids, lots of naturally } occurring compounds). The library search for matching probability often } gives me very strange kind of molecules with little meaning, and the total } ion scan lack the sensitivity needed for the detection of p.p.m. amounts } of contaminants. I could concentrate 100- to 1000-fold the extract, with } the sure result of great conyamination of liner, column, and even ion } source of quadrupole. } } Is there a rule for monitoring groups of compounds (e.g. fungicides, } phosphoric esters, halogenated compounds) by SIM of few peaks (up to 20) } and with a minimum number of injections ? Thanks for every kind of } suggestions ! } } Ermanno Errani I would first try to clean up your sample matrix (if you are not doing so already). Consult the literature for methods appropriate for the type of samples you are analyzing. -- Bill Cotham, Ph.D. Mass Spectrometry Laboratory Dept. of Chemistry and Biochemistry University of South Carolina Columbia, SC 29208 803-777-2039 (voice) 803-777-9521 (fax) ****************************************************************************** From: John Butler <72420.1527@CompuServe.COM> Date: 3 Feb 1997 21:39:23 GMT Subject: Re: LC-GC/MS Instrument Organization: TSP The Finnigan SSQ can also be configured for GC or LC. John Butler Thermo Quest ****************************************************************************** From: chthibault@aol.com Date: 4 Feb 1997 14:58:41 GMT Subject: US, NY, Syracuse--Job:Software Engineer, Embedded Systems Organization: AOL http://www.aol.com Leybold Inficon, Inc., located in central New York state, is looking for a Software Engineer responsible for developing and maintaining real-time, embedded software to control the operation of analytical instrumentation, acquire data, and transfer the data to other tasks or processors for subsequent processing. This position reports to the HAPS Software Manager. The successful candidate must be an experienced, self-motivated individual with strong communications and team skills, capable for working with minimal supervision. Minimum educational and work experience is a BS in computer science, electrical engineering, or related technical discipline, with at least 5 years experience or an advanced degree with 3 years experience. Technical experience is required in the following areas: - Real-Time programming including data acquisition, instrument control, and/or signal processing. - Embedded systems programming, including experience developing software where speed, memory and power consumption constraints are critical. - Multi-Task programming, including familiarity with such issues as inter-task communication, multi-task debugging, and parent-child task relations. - Extensive experience in C and some experience in assembly language are required. Experiance in the following areas would be helpful: - Experience with C++ or other object oriented languages would be a plus. - Scientific Programming experience and/or Gas Chromatography and Mass Spectrometry would be a plus. - Experience with various real time operating systems and kernels would be helpful (especially VxWorks). - Experience writing and debugging device drivers would also be helpful. Please send resumes and cover letters, with salary requirements to: Leybold Inficon, Inc. Human Resources, Dept CT 2 Technology Place E. Syracuse NY 13057 ======================================================================== Charlie Thibault Leybold Inficon, Inc ChThibault@aol.com 2 Technology Place (315)434-1268 E. Syracuse NY 13057 ****************************************************************************** From: markusg@hal2000.chemie.uni-mainz.de (Markus Gerle) Date: Tue, 04 Feb 97 21:00:16 GMT Subject: Re: Matrix solutions for MALDI Organization: university of mainz In article <5ctp2a$aul@acmez.gatech.edu>, U61985@UICVM.UIC.EDU wrote: }Can anyone tell me who sell matrix solutions for maldi? I know HP makes }those solutions but I don't have their catolog. Any informations are }welcome. Hello! Why are you interested in such solutions. Normally it is very easy to make the solutions by yourself. You just need the chemicals. For example if you are measuring polystyrene you should use Dithranol as the matrix and a silver-salt (e. g. AgCF3CO2) for enhancement of ionisation. The solvent would be THF. You can buy these chemicals from nearly every chemical supplier. The problem with MALDI is normally that you have to find out the best matrix composition for a specific problem. But I think that there are some people reading this group who can help you if you tell us somethink about the samples you want to measure. Best regards Markus Gerle ****************************************************************************** From: Martin@nezumi.demon.co.uk (Martin Tom Brown) Date: Tue, 04 Feb 97 10:40:55 GMT Subject: Re: ICP-MS Aqueous Sn? Organization: Nezumi In article <5d5lhc$1l@acmex.gatech.edu> jdglowac@facstaff.wisc.edu "John Glowacki" writes: } I'm looking for some input on running trace level Sn analysis by ICP-MS } on surface water samples. Interference equation? } } Thanks in advance. So many isotopes to choose from - one must be interference free. Unless there are high levels of precious metals or tellurium in local surface water Sn118 & Sn120 should be relatively clear. I don't know if Argon trimer causes any trouble though. Regards, -- Martin Brown __ CIS: 71651,470 Scientific Software Consultancy /^,,)__/ ****************************************************************************** From: "Kenneth P. Matuszak" Date: Tue, 04 Feb 1997 16:11:21 -0600 Subject: Reference papers on FC-43 (perfluorotributylamine) Organization: Abbott Labs In the process of validating our mass spec systems, we decided it would be nice to actually have reference papers (preferably refereed journal articles) for each of our chosen mass spec standards. While we have used FC-43 (perfluorotributylamine) in our GC/MS systems for years, we have always referred to tables provided by the FC-43 supplier. Is anyone aware of such papers on FC-43 for positive EI, positive CI, and negative CI? So far we haven't had much success at literature searches (except for some leads on negative CI), although admittedly we could be bungling those. We would be looking for tables of the normally observed ions with masses correct to at least with 0.1 amu. -- Ken M. ****************************************************************** * Ken Matuszak, Ph.D. kenm@cid.pprd.abbott.com * * Abbott Laboratories TEL: (847) 938-9225 * * D418, AP31 FAX: (847) 938-9226 * * 200 Abbott Park Road * * Abbott Park, IL 60064-3537 * ****************************************************************** ****************************************************************************** From: Amish Desai Date: Tue, 04 Feb 1997 14:36:01 -0800 Subject: mass spec future market Organization: CIT Micromachining Group Hello, I am doing a report on mass spectrometry. Specifically, the economics and the future market. I'm trying to find out where I can get some articles or information on this. Any help would be appreciated. I don't normally read/post to this newsgroup so please email. Thank you, Amish ****************************************************************************** From: Christopher Kaine Date: Tue, 04 Feb 1997 20:08:42 -0800 Subject: Re: LC-GC/MS Instrument Organization: OneNet Communications HUB News Server David Sparkman wrote: } } On Tuesday January 28 Witold Winnik, Ph.D. wrote looking for an instrument } that will do EI/CI GC/MS and can be switched to ESI LC/MS. One of the } best instruments for this is the Finnigan/ATI Automass built in Paris. } This instrument was desiged to work along these lines. It is currently } being sold by Finnigan out of Austin, Texas. } } O. David Sparkman } Consultant-At-Large } } Phone: 1-510-754-5003 I believe the individual was looking for a MS/MS instrument. If that is the case, then really the Finnigan TSQ7000, Sciex or the Micromass Quattro fit the bill. Christopher J. Kaine ****************************************************************************** From: Chris Elhardt Date: 5 Feb 1997 13:57:19 GMT Subject: Re: LDV - schematics ?? Organization: Texas Department of Health Contact National Instruments, Austin, TX. cElhardt yamx0001@gold.tc.umn.edu wrote: }I am a physics student at the U of MN. }I'm developing an experiment and need to implement a }Laser-Doppler Velocitometer (LDV), in order to measure }the velocity of Couette-Taylor fluid flow. I only need to measure }1 dimension, and don't need anything fancy of sophisticated. } }Can anyone help me out with schematics for transmitting and }receiving circuits, and interfacing with a PC? } }I have lasers. I just don't know how to design the circuits. } }Please post or email me would be better. } }Thanks. Patrick yamx0001@gold.tc.umn.edu } } ****************************************************************************** From: "Achim Recktenwald, PhD" Date: Wed, 05 Feb 1997 12:39:45 -0500 Subject: Re: Matrix solutions for MALDI Organization: IBEX Technologies, Inc., Biochemistry, 5485 Pare, Montreal, PQ, H4P 1P7, Canada Markus Gerle wrote: } } In article <5ctp2a$aul@acmez.gatech.edu>, U61985@UICVM.UIC.EDU wrote: } }Can anyone tell me who sell matrix solutions for maldi? I know HP makes } }those solutions but I don't have their catolog. Any informations are } }welcome. } } Hello! } } Why are you interested in such solutions. Normally it is very easy to make } the solutions by yourself. You just need the chemicals. For example if you } are measuring polystyrene you should use Dithranol as the matrix and a } silver-salt (e. g. AgCF3CO2) for enhancement of ionisation. The solvent } would be THF. You can buy these chemicals from nearly every chemical } supplier. The problem with MALDI is normally that you have to find out } the best matrix composition for a specific problem. But I think that there } are some people reading this group who can help you if you tell us } somethink about the samples you want to measure. } } Best regards } Markus Gerle For lots of stuff for MALDI check out: http://chait-sgi.rockefeller.edu/ HP's MALDI-stuff you'll find at: http://www-dmo.external.hp.com:80/apg/main.html Achim ****************************************************************************** From: "Richard B. van Breemen" Date: Wed, 5 Feb 1997 16:33:17 -0600 (CST) Subject: Finnigan MAT 90 Organization: * FOR SALE: Finnigan MAT 90 reversed geometry magnetic sector mass spectrometer equipped with FAB, EI, CI, DCI and a Varian 3400 GC for GC-MS. This instrument has been well maintained and is currently the workhorse high resolution, FAB and GC-MS instrument on campus. However, it will be replaced by a newer model. The MAT 90 is available immediately. Please contact either of us for more details and to make your best offer: Richard B. van Breemen University of Illinois at Chicago Department of Medicinal Chemistry and Pharmacognosy 833 S. Wood St. Chicago, IL 60612-7231 email: richard.vanbreemen@uicvm.uic.edu Telephone: (312) 996-9353 FAX: (312) 996-7107 or Duane L. Venton University of Illinois at Chicago Department of Medicinal Chemistry & Pharmacognosy 833 S. Wood St. Chicago, IL 60612-7231 email: venton@uicvm.uic.edu Telephone: (312) 996-5233 FAX: (312) 996-7107 ****************************************************************************** From: Philip Berger Date: Thu, 06 Feb 1997 05:49:35 GMT Subject: Re: Teknivent Corp. [1/1] Organization: Netcom In response to numerous inquiries in this news group, I felt that an announcement other than those already released would be in order. On December 10, Teknivent Corp. sold its assets to ProLab Resources, Inc. of Madison, WI. During its 20+ years of service to the international mass spectrometry community, Teknivent automated over 1000 GC/LC-MS instruments manufactured by nearly every commercial vendor here and abroad. We had the pleasure of working with such pioneering organizations as Extrel, Vestec, Hitachi, Finnigan and a host of other manufacturers as a contractor or OEM supplier. As our products were often the only ones that could automate many of the older instruments still actively in use, they offered a new lease on life to these high-cost investments, greatly extending their useful life cycle. Our Vector(TM) Series data systems (Vector/One and Vector/Two) introduced in 1983 and 1990, respectively, set the standard in PC-based MS automation, with free software upgrades for the life of these units. More recently, our Envirolink(TM) data system has become the most popular retrofit for environmental GC/MS instruments. As a young entrepreneur in 1976, I believed that computers (mini’s, in those days!) could be cost-effectively produced that would greatly simplify the work of professional mass spectrometrists and routine operators by providing far better analyses with less operator fatigue. Through our three product generations, we were fortunate to be able to work with many of the leading chemists in this field and will always cherish their ideas, energy and enthusiasm in "test driving" our earliest--and often clumsiest--offerings. To the vendors with whom we worked in customizing our designs to their wide-ranging instrument and application requirements, I am particularly indebted for your faith in the talents of our small working group and its ability to provide innovative, economical solutions that allowed your companies to quickly move into target markets with fully automated products. As I leave Teknivent to pursue other dreams, I want to thank all of our customers for their many years of loyal patronage and for their thousands of hours of interactive discussions that helped shape our company'’s direction, its products, and most importantly, its culture. To Keith Martinko, founder and CEO of ProLab Resources, Inc.(http://www.prolab.com), I wish you and your colleagues every good fortune as you inherit the legacy we established together. Best wishes for a healthy and happy new year. Philip S. Berger President and CEO ****************************************************************************** From: E.A.Underwood@exeter.ac.uk Date: Thu, 6 Feb 1997 14:50:46 +0000 (GMT) Subject: HANDS ON MASS SPEC Organization: * Dear All, I have been asked to find out availability and prices of mass spectrometers that might be suitable for hands on use by post graduate students and undergraduates who are working on research projects as part of their degree course. The department mass spec service is run on a Kratos Profile mass spectrometer, capable of low and high resolution in EI, CI, and LSIMS modes. The system has a GC interface and a solids probe, and must be shut down to change over to LSIMS. Masses up 2400 amu are routinely obtainable. Our case for getting a share of the limited funds available would be improved if, as well as being capable of routine work, we could extend the range of mass spec facilities in the department with a single purchase. I would very much appreciate hearing from anyone with experience of hands on mass spectrometers, or suggestions as to which instrument manufacturers we might approach. This request has been mailed to other relevant lists, and I apologise to those of you who receive duplicates. Thank you all in advance for your help, Eric Underwood. Mr Eric Underwood Tel 01392-263438 Spectroscopic Services Department of Chemistry University of Exeter Fax 01392-263434 Stocker Road Exeter EX4 4QD E-mail E.A.Underwood@exeter.ac.uk "Everything not compulsory is forbidden" ****************************************************************************** From: John Subject: HELP! HP MS Chemstation Pascal software Date: Wed, 05 Feb 1997 21:51:26 GMT HP 5890A + 5970 MSD with 9000/300 computer and 9153B hard/floppy The hard drive has died on our 9153B and we no longer have the original disks. Can anybody help with a copy of v3.1 or 3.2? HP aren't interested and can't supply. Any help with sourcing a replacement 20Mb drive would also be appreciated! Hope somebody can help. John email: johncleg@epichem.co.uk ****************************************************************************** From: (David Bostwick) Date: Fri, 7 Feb 1997 00:13:27 -0500 (EST) Subject: Power outage Organization: * Most computer systems at Georgia Tech will be unavailable from 0400 EST Saturday, February 8, until 0700 EST Tuesday, February 11 to complete the installation and testing of several UPSes. This outage will include the machine from which sci.techniques.mass-spec is moderated. No new messages will be approved, and e-mail will not be accepted. Most UNIX mailers will continue sending messages for up to 5 days, and will give a warning message to the sender. Other mailers may simply report the failure and will not try to send the message again. We regret the disruption. We will check the system regularly, and will begin approving messages again as soon as possible. -- David E. Bostwick Georgia Institute of Technology, Atlanta, GA, 30332 david.bostwick@chemistry.gatech.edu ****************************************************************************** From: lcpo@unice.fr (J.-F. Gal) Date: Tue, 11 Feb 1997 08:21:16 +0000 Subject: Reference papers on FC-43 (perfluorotributylamine) Organization: * To the attention : "Kenneth P. Matuszak" Date: Tue, 04 Feb 1997 16:11:21 -0600 Subject: Reference papers on FC-43 (perfluorotributylamine) Organization: Abbott Labs It may help to read : "Chemical mass markers in CI-MS", D.V. Bowen, F.H. Field; Anal. Chem. 1975;47(13); 2289-2292 -(n-C4H9)3N is discussed. I didn't find a ref to the EI ms in this paper anyway. Jean-Francois Gal ****************************************************************************** From: "Greg R. Shaw" Date: Mon, 10 Feb 1997 13:12:07 -0800 Subject: GC/MS Position Available Organization: West Coast Analytical Service Job Title: GCMS Operator Job Description: West Coast Analytical Service, Inc. (WCAS) is looking for chemists that are experienced GCMS operators. This experience must include work on environmental samples for volatiles and semivolatiles as well as screens of unknown materials. Experience with pharmaceuticals and air samples would be an advantage. Must have a minimum of a B.S. degree, over 5 years experience, able to solve problems, repair instruments, only interested in high quality work, can work under strict deadlines, and has excellent organizational skills. Please Contact Eric Lindsay eric.lindsay@wcaslab.com 9840 Alburtis Ave Santa Fe Springs, CA 90670 Voice (562)948-2225 Fax (562)948-5850 -- Greg R. Shaw West Coast Analytical Service greg.shaw@wcaslab.com 9840 Alburtis Avenue Phone: (562) 948-2225 Santa Fe Springs, CA 90670 Fax : (562) 948-5850 http://www.wcaslab.com ****************************************************************************** From: eri@mindlink.bc.ca (Elemental Research Inc.) Date: Mon, 10 Feb 1997 19:48:55 GMT Subject: VG PQ-I Spare parts available Organization: MIND LINK! - British Columbia, Canada Some months ago I posted a list of spare parts we have available for a VG PQ-I ICP-MS (ours finally died). We sold many of them, but still have a few left. Just in case anyone missed the first post, this is what we have left: A. Working Units ------------- Lens supply (s/n 1894-05) $700.00 Lens supply (s/n 1993-03) $700.00 Power control (s/n 3001) $ 450.00 RF coupler $ 250.00 B. Main power board PCB's: ----------------------- MR504-200C3 issue 2 (1) $ 100.00 each MR504-204C3 issue 3 (1) $ 100.00 each MR504-207C3 issue 1 (2) $ 100.00 each MR504-202C2 issue 5 (2) $ 100.00 each MR504-205C3 issue 3 (2) $ 100.00 each MR504-201C3 issue 2 (4) $ 100.00 each MR504-203C3 issue 2 (2) $ 100.00 each MR504-2013C3 issue 1 (2) $ 100.00 each C. Quad Controller Boards ------------------------- MA 3020-200 P/D (1) $100.00 MA 495-69C (1) $100.00 MA 495-70C (1) $100.00 MA 495-63C (1) $100.00 MA 495-65C (1) $100.00 MA 495-76C (1) $100.00 MA 485-62C (1) $100.00 D. Instrument controller boards ------------------------------- PACTROL BOARD (2) $ 100.00 each E. Other -------- Edwards vacuum controller Model 1105 $1500.00 Gilson 222 autosampler $4000.00 Quad RF generator, valve type $1000.00 Lense stack $4000.00 (all prices in $US) 20% off the above prices if you buy a large part of the above. Cheers, Ray Ford Elemental Research Inc. 309-267 West Esplanade North Vancouver, BC V7M 1A5 Canada (604) 986-0445 (604) 986-0071 eri@mindlink.bc.ca ****************************************************************************** From: Tomasz Gibinski Date: Mon, 10 Feb 1997 13:01:13 +0100 Subject: Detection fullerenes in MS Organization: Adam Mickiewicz University Which metod is the most propriet for detection of C60 ? gibi@chem.amu.edu.pl ****************************************************************************** From: nathand@cco.caltech.edu (Nathan Dalleska) Date: 11 Feb 1997 00:39:29 GMT Subject: Re: LC-GC/MS Instrument Organization: California Institute of Technology If you can afford to shell out the big bucks and happen to need high resolution (or can use HR to solve some of your problems) Micromass' ProSpec is a chromatography workhorse. A FFR gas cell and linked scans will do decent MS/MS. -Nathan Dalleska -- Nathan F. Dalleska, Ph.D. CCE Mass Spectrometry Laboratory California Institute of Technology138-78 Pasadena, CA 91125 818.395.6533 nathand@cco.caltech.edu ****************************************************************************** From: vanreet@ilink.nis.za (Teunis vanRee) Date: 9 Feb 1997 13:41:52 GMT Subject: Re: Looking for nice GCMS demo Organization: Network Information Services We expect delivery of our new GCQ any moment now, and are planning a 'commissioning' function to show the donors and management where the money went. We would like to demonstrate the instrument with some simple but interesting (to laymen) separation & identification. Any suggestions would be more than welcome. Thanks Thomas ****************************************************************************** From: Keith Martinko Date: Tue, 11 Feb 1997 11:34:36 -0600 Subject: Teknivent Corp. purchased by ProLab Resources, Inc. Organization: ProLab Resources, Inc. To all members of the mass spec community : ProLab Resources, an innovative software and hardware development firm headquartered in Madison, WI, is proud to announce the acquisition of Teknivent Corp. and it's Vector/Two and EnviroLink PC-based mass spectrometry data system products. As a former Vice President of Product Development at Teknivent Corp. for over seven years, I am excited to once again lead the effort within ProLab Resources to improve this unique technology to better serve your needs and the needs of the analytical laboratory marketplace. During this year, we plan to invest heavily in developing new features for both product lines and expanding the base of mass spectrometers supported by this technology. For up-to-date information, please visit us anytime at http://www.prolab.com. ProLab Resources' realizes that one of the greatest assets behind the Teknivent product line is it's large base of talented and dedicated customers. If you are a Teknivent Owner, your ideas have helped to significantly improve the performance of both the Vector/Two and EnviroLink data systems. Although Teknivent is no longer available to service your existing products, ProLab Resources is available to provide continued support for your Teknivent systems. To aid in providing support continuity for your laboratory, ProLab Resources has retained the technical services of both Lindsay McAnulty and Bill Bertrand, previously Senior Support Engineers at Teknivent Corp.. Their intimate knowledge of your laboratory configuration and specific application needs will help ProLab Resources to quickly provide the highest level of support for your systems. Finally, I would like to personally thank all Teknivent customers for your past support of Teknivent and its products, and all of us at ProLab Resources look forward to establishing a new relationship with your organization. We look forward to hearing from you soon and please feel free to email me at prolab@ix.netcom.com or call me at 608-278-0002 if you have any additional questions. Best regards, Keith Martinko President ProLab Resources, Inc. prolab@ix.netcom.com http://www.prolab.com ****************************************************************************** From: "Greg R. Shaw" Date: Tue, 11 Feb 1997 11:50:23 -0800 Subject: Finnigan 4500 for Sale Organization: West Coast Analytical Service For sale: Finnigan 4500 quadrupole GC/MS/DS. 2-1024 mass range, 9610 GC, dual diffusion pump, solids probe, -3kV dynode, Incos Rev 6.5 software (including 42000 entry NIST library), Printronix MVP printer, 70 Mb Winchester drive, Cipher streamer tape. Includes user and service manuals, full schematics. Please Contact: eric.lindsay@wcaslab.com -- Eric Lindsay West Coast Analytical Service eric.lindsay@wcaslab.com 9840 Alburtis Avenue Phone: (562) 948-2225 Santa Fe Springs, CA 90670 Fax : (562) 948-5850 http://www.wcaslab.com ****************************************************************************** From: PAREESDM@apci.com Date: Tue, 11 Feb 1997 18:01:26 -0500 Subject: response to Winnik and Cotham Organization: * Witold Winnik, Ph.D. wrote: } } Hello, } } I am trying to find a mass spectrometer which can perform the following tasks: } 1. reasonably easily switches between GC/MS and LC-electrospray jobs (one } week it would perform a GC/MS analysis and following weeks LC/MS, for } example) } 2. capable of EI / CI and positive / negative ionization } 3. performs MS and MS/MS analysis; mass range up to 3000-4000 m/z } And costs below $400,000. } } I know that Finnigan GCQ and LCQ ion traps would qualify jointly but the } problem is I can request only one instrument in my proposal, even though it } would be probably less expensive to acquire both GCQ and LCQ instead of one } instrument that can switch between GC and LC jobs. } If anyone knows about such instrument, or has been using it please contact } me at: winnik@charlotte.med.nyu.edu } } Witold Winnik } NYU Medical Center And Bill Cotham responded: }I think a Finnigan TSQ or a Micromass Quatro would meet all of your }specs. Well, I have one of each of these instruments in my lab. I can't speak to the issue of doing electrospray on the 7000 but it does excellent EI and CI. However, while our electrospray on the Quattro has been problematic the EI and CI was dismal. In fact it was the incredibly poor performance of this system in EI and CI modes that caused us to purchase the 7000. The EI spectra were frequently biased severely toward low mass ions. For example, sometimes the base ion for toluene would be at m/z = 39. This was not a tuning issue. CI was also a problem, with significant fragmentation that we've never seen on other instruments. It is possible that Micromass has redesigned the source and these problems have been solved, but I'd certainly scrutinize this closely before making a decision. Dave Parees pareesdm@apci.com my comments are not associated with my employer ****************************************************************************** From: "Karl J. Treier" Date: 12 Feb 1997 01:48:06 GMT Subject: ITS40, Magnum & GCQ Users ! Organization: UniTech Attention ITS40, Magnum and GCQ GCMS Users, now available... MS2TXT Convert .MS datafiles into delimited ASCII files for easy import into Spreadsheet or Database software, available in Windows 3.1 and 95/NT versions for $249 + Shipping. MS2HP Convert .MS datafiles into HP Chemstation (.D) format, available in Windows 3.1 and 95/NT versions for $249 + Shipping. SPL2BMP Convert .SPL Spooler files into individual .BMP graphics files for easy import into graphics programs, available in Windows 3.1 and 95/NT versions for $149 + Shipping. Finally it's really available, sorry for the interminable delays. The two volume Procedure Language Reference Manual Set, almost 1000 pages of invaluable documentation for $495 + Shipping. -- UniTech 680 Northland Boulevard, Suite 9 Cincinnati OH 45240, USA Phone: 1-800-989-0144 or (513) 825-0144 Fax: (513) 825-0163 e-mail: info@uni-tech.com web site: http://www.uni-tech.com ****************************************************************************** From: